Protocols for the Syntheses of 2,2 '-Bis(indolyl)arylmethanes, 2-Benzylated lndoles, and 5,7-Dihydroindolo[2,3-b]carbazoles
Özet
The electrophilic substitution reaction of 4,7-dihydroindole with aryl-aldehydes as an electrophilic partner followed by an oxidation step to deliver 2,2'-bis(indolyl)arylmethanes was studied for the first time. The reaction afforded regioselectivity at the 2,2'-positions of indole in an operationally simple and inexpensive procedure with a variety of substrates. To the best of our knowledge, this is the first set of examples of 2,2'-bis(indolyl)arylmethanes obtained in a substituent-free manner. A facile method from dipyrromethanes to the corresponding 2-benzylindoles was also reported. In addition, 2,2'-bis(indolyl)arylmethanes were converted to 5,7-dihydroindolo[2,3-b]carbazoles.
Atıf için künye
Lafzi, F., Kılıç, H., & Saraçoğlu, N. (2019). Protocols for the Syntheses of 2,2 '-Bis(indolyl)arylmethanes, 2-Benzylated lndoles, and 5,7-Dihydroindolo[2,3-b]carbazoles. JOURNAL OF ORGANIC CHEMISTRY, 84(18), 12120–12130. https://doi.org/10.1021/acs.joc.9b02124
BibTeX
@article{lafzi2019-55529,
author = {Lafzi, Ferruh and Kılıç, Haydar and Saraçoğlu, Nurullah},
title = {Protocols for the Syntheses of 2,2 '-Bis(indolyl)arylmethanes, 2-Benzylated lndoles, and 5,7-Dihydroindolo[2,3-b]carbazoles},
journal = {JOURNAL OF ORGANIC CHEMISTRY},
year = {2019},
volume = {84},
number = {18},
pages = {12120--12130},
issn = {0022-3263},
doi = {10.1021/acs.joc.9b02124},
url = {https://akademik.atauni.edu.tr/yayinlar/55529-protocols-for-the-syntheses-of-22-bisindolylarylmethanes-2-benzylated-lndoles}
}