Metal- and Additive-Free C3-Functionalization of Imidazo[1,2-a]pyridines with para-Quinone Methides

Lafzi, Ferruh; Kılıç, Haydar

doi:10.1002/ajoc.202100313

Makale Tam Makale Uluslararası 2021

Metal- and Additive-Free C3-Functionalization of Imidazo[1,2-a]pyridines with para-Quinone Methides

Ferruh Lafzi, Haydar Kılıç

ASIAN JOURNAL OF ORGANIC CHEMISTRY Cilt 10 · Sayı 7 · ss. 1814–1821 · 01.07.2021

DOI ile aç

Özet

Metal- and additive-free C3-alkylation of imidazo[1,2-a]pyridines with para-quinone methides (p-QMs) has been realized. 1,6-Nucleophilic addition of imidazopyridines to p-QMs were carried out under mild conditions in very excellent yields. Furthermore, we performed late-stage drug functionalization for zolimidine. All transformations proceeded with broad substrate scope and good functional group tolerance.

Anahtar kelimeler

1 Imidazo[1 2-a]pyridine HFIP para-quinone methide zolimidine 6-nucleophilic addition

Atıf için künye

Lafzi, F., & Kılıç, H. (2021). Metal- and Additive-Free C3-Functionalization of Imidazo[1,2-a]pyridines with para-Quinone Methides. ASIAN JOURNAL OF ORGANIC CHEMISTRY, 10(7), 1814–1821. https://doi.org/10.1002/ajoc.202100313

BibTeX

@article{lafzi2021-55528,
  author = {Lafzi, Ferruh and Kılıç, Haydar},
  title = {Metal- and Additive-Free C3-Functionalization of Imidazo[1,2-a]pyridines with para-Quinone Methides},
  journal = {ASIAN JOURNAL OF ORGANIC CHEMISTRY},
  year = {2021},
  volume = {10},
  number = {7},
  pages = {1814--1821},
  issn = {2193-5807},
  doi = {10.1002/ajoc.202100313},
  url = {https://akademik.atauni.edu.tr/yayinlar/55528-metal-and-additive-free-c3-functionalization-of-imidazo12-apyridines-with-para}
}