Paracetamol sensing with a flexible graphene paper electrode modified with MnCo2O4

BACKGROUND: The design of new-generation flexible sensors for medical applications has gained considerable interest in the research community in recent past years. Herein, a free-standing flexible electrode was developed for the electrochemical determination of Paracetamol (PC). This graphene-based paper electrode was prepared using graphene and MnCo2O4 dispersion with a mold-casting method followed by chemical reduction. The morphology and structure of our flexible paper electrode (MnCo2O4/GP) were characterized by scanning electron microscopy, energy-dispersive, X-ray diffraction, X-ray photoelectron, and Raman spectroscopy. RESULTS: The as-prepared flexible MnCo2O4/GP showed outstanding sensing performance for PC, as compared to GP, due to the excellent electrochemical properties of MnCo2O4. The proposed sensor exhibited a wide linear range of 4.64-1000 mu M for electrochemical determination of PC with a low detection limit of 1.39 mu M. Furthermore, MnCo2O4/GP was successfully applied for PC syrup and tablets with good accuracy results. CONCLUSIONS: For the first time, the present study demonstrated the fabrication and utilization of MnCo2O4-modified graphene paper to develop a flexible and sensitive electrode for monitoring PC. (c) 2024 The Author(s). Journal of Chemical Technology and Biotechnology published by John Wiley & Sons Ltd on behalf of Society of Chemical Industry (SCI).