Electrochemical C–H trifluoromethylation of 4-phenylthiazol-2-amines

Yeşilyurt, İsa; Dağalan, Ziya; Anıl, Barış; Koçak, Ramazan; Bayrakçeken Nişancı, Fatma; Nişancı, Bilal

doi:10.1039/d5ob01958c

Makale Tam Makale Uluslararası 2026

Electrochemical C–H trifluoromethylation of 4-phenylthiazol-2-amines

İsa Yeşilyurt, Ziya Dağalan, Barış Anıl, Ramazan Koçak, Fatma Bayrakçeken Nişancı, Bilal Nişancı

Organic and Biomolecular Chemistry Cilt 24 · Sayı 7 · ss. 1434–1439 · 01.01.2026

DOI ile aç

Özet

Herein, we report a new methodology for the electrochemical oxidative C–H trifluoromethylation of 4-phenylthiazol-2-amines in an undivided cell using a glassy carbon electrode (GCE) and sodium trifluoromethanesulfinate (CF3SO2Na; Langlois’ reagent) as the CF3 radical source. Using this tert-butyl hydroperoxide (TBHP)-mediated and transition metal-free effective approach, trifluo-romethylated 4-phenylthiazol-2-amines were synthesized in high yields (up to 97%).

Atıf için künye

Yeşilyurt, İ., Dağalan, Z., Anıl, B., Koçak, R., Bayrakçeken Nişancı, F., & Nişancı, B. (2026). Electrochemical C–H trifluoromethylation of 4-phenylthiazol-2-amines. Organic and Biomolecular Chemistry, 24(7), 1434–1439. https://doi.org/10.1039/d5ob01958c

BibTeX

@article{yesilyurt2026-54190,
  author = {Yeşilyurt, İsa and Dağalan, Ziya and Anıl, Barış and Koçak, Ramazan and Bayrakçeken Nişancı, Fatma and Nişancı, Bilal},
  title = {Electrochemical C–H trifluoromethylation of 4-phenylthiazol-2-amines},
  journal = {Organic and Biomolecular Chemistry},
  year = {2026},
  volume = {24},
  number = {7},
  pages = {1434--1439},
  issn = {1477-0520},
  doi = {10.1039/d5ob01958c},
  url = {https://akademik.atauni.edu.tr/yayinlar/54190-electrochemical-c-h-trifluoromethylation-of-4-phenylthiazol-2-amines}
}