Structural and functional characterization of simvastatin-induced myotoxicity in different skeletal muscles

Şimşek Özek, Nihal; Bal, I. Burak; Sara, Yildirim; Onur, Rustu; Severcan, Feride

doi:10.1016/j.bbagen.2013.09.010

Makale Tam Makale Uluslararası 2014

Structural and functional characterization of simvastatin-induced myotoxicity in different skeletal muscles

Nihal Şimşek Özek, I. Burak Bal, Yildirim Sara, Rustu Onur, Feride Severcan

BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS Cilt 1840 · Sayı 1 · ss. 406–415 · 01.01.2014

DOI ile aç

Özet

Background: Statins are the most commonly used drugs for the treatment of hypercholesterolemia. Their most frequent side effect is myotoxicity. To date, it remains unclear whether statins preferentially induce myotoxicity in fast- or in slow-twitch muscles. Therefore, we investigated these effects on fast- (extensor digitorum longus; EDL), slow- (soleus; SOL), and mixed-twitch muscles (diaphragm; DIA) in rats by comparing their contractile and molecular structural properties.

Anahtar kelimeler

LIPID-PEROXIDATION GENE-EXPRESSION Rat Fourier transform-infrared spectroscopy TRANSFORM INFRARED-SPECTROSCOPY Statin Extensor digitorum longus Soleus Diaphragm Contractility COA REDUCTASE INHIBITORS COENZYME-A REDUCTASE RYANODINE RECEPTORS MEMBRANE FLUIDITY CHOLESTEROL

Atıf için künye

Şimşek Özek, N., Bal, I. B., Sara, Y., Onur, R., & Severcan, F. (2014). Structural and functional characterization of simvastatin-induced myotoxicity in different skeletal muscles. BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS, 1840(1), 406–415. https://doi.org/10.1016/j.bbagen.2013.09.010

BibTeX

@article{simsekozek2014-54110,
  author = {Şimşek Özek, Nihal and Bal, I. Burak and Sara, Yildirim and Onur, Rustu and Severcan, Feride},
  title = {Structural and functional characterization of simvastatin-induced myotoxicity in different skeletal muscles},
  journal = {BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS},
  year = {2014},
  volume = {1840},
  number = {1},
  pages = {406--415},
  issn = {0304-4165},
  doi = {10.1016/j.bbagen.2013.09.010},
  url = {https://akademik.atauni.edu.tr/yayinlar/54110-structural-and-functional-characterization-of-simvastatin-induced-myotoxicity-in}
}