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Makale Tam Makale Uluslararası 2019

Propolis and Its Combination with Boric Acid Protect Against Ischemia/Reperfusion-Induced Acute Kidney Injury by Inhibiting Oxidative Stress, Inflammation, DNA Damage, and Apoptosis in Rats

Fatime Geyikoğlu, Kübra Koç, Suat Çolak, Hüseyin Serkan Erol, Salim Cerig, Berna Kavakcioglu Yardimci, Ozge Cakmak, Muhammed Bahaeddin Dortbudak, Gizem Eser, Ferhunde Aysin, Nihal Şimşek Özek, Serkan Yıldırım

Biological Trace Element Research Cilt 192 · Sayı 2 · ss. 214–221 · 01.12.2019
DOI ile aç

Özet

Ischemia reperfusion (I/R) injury which causes kidney dysfunction is one of the most studied diseases directly linked to oxidative stress. In this regard, it is important to protect cells against damage by inducing antioxidant response. Herein, we aimed to evaluate the therapeutic roles and possible mechanisms of propolis and boric acid in kidney I/R injury based on relevant basic research and clinical studies. Sprague-Dawley rats were subjected to 50 min of ischemia followed by 3 h of reperfusion. Animals were randomly divided into a control group (the abdominal wall was just opened and closed), an I/R injury group, the propolis intervention group (200 mg/kg, intragastric administration, 1 h before ischemia), boric acid intervention group (14 mg/kg, intragastric administration 1 h before ischemia), and the propolis + boric acid intervention group (intragastric administration 1 h before ischemia). Kidney function, the antioxidant defensive system, and renal damage were assessed. In addition, the oxidative stress and inflammatory status were estimated in renal tissue. Furthermore, DNA damageand apoptosis were detected by immunohistochemistry. When compared with I/R group, propolis alone and especially propolis + boric acid groups significantly improved functional parameters. While the antioxidant response was increased, renal injury size and apoptosis were significantly decreased in both groups. Also, the MDA and TNF-alpha levels besides the 8-OHdG formation were downregulated. According to these outcomes, it can be said that especially propolis together with boric acid ameliorates kidney injury caused by I/R through acting as an antioxidant, anti-inflammatory, and antiapoptotic agent. In conclusion, propolis alone and its combination with boric acid could be developed as therapeutic agents against serious renal I/R injuries.

Anahtar kelimeler

oxidative stress INFLAMMATION kidney Boric acid ischemia-reperfusion propolis

Atıf için künye

Geyikoğlu, F., Koç, K., Çolak, S., Erol, H. S., Cerig, S., Yardimci, B. K., Cakmak, O., Dortbudak, M. B., Eser, G., Aysin, F., Şimşek Özek, N., & Yıldırım, S. (2019). Propolis and Its Combination with Boric Acid Protect Against Ischemia/Reperfusion-Induced Acute Kidney Injury by Inhibiting Oxidative Stress, Inflammation, DNA Damage, and Apoptosis in Rats. Biological Trace Element Research, 192(2), 214–221. https://doi.org/10.1007/s12011-019-1649-2

BibTeX 
@article{geyikoglu2019-54049,
  author = {Geyikoğlu, Fatime and Koç, Kübra and Çolak, Suat and Erol, Hüseyin Serkan and Cerig, Salim and Yardimci, Berna Kavakcioglu and Cakmak, Ozge and Dortbudak, Muhammed Bahaeddin and Eser, Gizem and Aysin, Ferhunde and Şimşek Özek, Nihal and Yıldırım, Serkan},
  title = {Propolis and Its Combination with Boric Acid Protect Against Ischemia/Reperfusion-Induced Acute Kidney Injury by Inhibiting Oxidative Stress, Inflammation, DNA Damage, and Apoptosis in Rats},
  journal = {Biological Trace Element Research},
  year = {2019},
  volume = {192},
  number = {2},
  pages = {214--221},
  issn = {0163-4984},
  doi = {10.1007/s12011-019-1649-2},
  url = {https://akademik.atauni.edu.tr/yayinlar/54049-propolis-and-its-combination-with-boric-acid-protect-against-ischemiareperfusion}
}