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Makale Tam Makale Uluslararası 2021 Açık erişimli

Inula graveolens induces selective cytotoxicity in glioblastoma and chronic leukemia cells

Kübra Koç, Ferhunde Aysin, Nihal Simsek Ozek, Fatime Geyikoğlu, Ali Taghizadehghalehjoughi, Ozlem Ozgul Abuc, Ozge Cakmak, Gülşah Yıldız Deniz

REVISTA DA ASSOCIACAO MEDICA BRASILEIRA Cilt 67 · Sayı 12 · ss. 1771–1778 · 01.01.2021
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Özet

OBJECTIVE: Crude oil extracts, components of extracts, and ethanolic extracts of Inula graveolens possess various pharmacological activities on various cancer cells including antioxidative and antiproliferative effects. Aqueous extract of this species has not been investigated on the liquid malignancies and solid tumors with a high incidence of treatment refractoriness and poor survival outcomes such as glioblastoma and leukemia. Hence, the present study aimed to evaluate the cytotoxic efficiency of I. graveolens aqueous extracts on human glioblastoma multiforme and chronic myelogenous leukemia cell lines in comparison to non-cancerous primary rat cerebral cortex and human peripheral blood mononuclear cells.

Anahtar kelimeler

EXPRESSION IN-VITRO AGENTS apoptosis CHEMICAL-COMPOSITION ESSENTIAL OIL cell viability GLIOBLASTOMA Myeloid leukemia Inula DOWN-REGULATION TEMOZOLOMIDE

Sürdürülebilir Kalkınma Amaçları

  • SKA 3: Sağlıklı Bireyler

Atıf için künye

Koç, K., Aysin, F., Ozek, N. S., Geyikoğlu, F., Taghizadehghalehjoughi, A., Abuc, O. O., Cakmak, O., & Yıldız Deniz, G. (2021). Inula graveolens induces selective cytotoxicity in glioblastoma and chronic leukemia cells. REVISTA DA ASSOCIACAO MEDICA BRASILEIRA, 67(12), 1771–1778. https://doi.org/10.1590/1806-9282.20210614

BibTeX 
@article{koc2021-54044,
  author = {Koç, Kübra and Aysin, Ferhunde and Ozek, Nihal Simsek and Geyikoğlu, Fatime and Taghizadehghalehjoughi, Ali and Abuc, Ozlem Ozgul and Cakmak, Ozge and Yıldız Deniz, Gülşah},
  title = {Inula graveolens induces selective cytotoxicity in glioblastoma and chronic leukemia cells},
  journal = {REVISTA DA ASSOCIACAO MEDICA BRASILEIRA},
  year = {2021},
  volume = {67},
  number = {12},
  pages = {1771--1778},
  issn = {0104-4230},
  doi = {10.1590/1806-9282.20210614},
  url = {https://akademik.atauni.edu.tr/yayinlar/54044-inula-graveolens-induces-selective-cytotoxicity-in-glioblastoma-and-chronic}
}