Synthesis of the possible carcinogenic dihydrodiol and diol epoxide of phthalazine
Özet
Inverse-Diels-Alder reaction of dimethyl 1,2,4,5 -tetrazine-3,6-dicarboxylate with benzene cis-diol gave dihydrodiol coninini 2 the 1,4-dihydropyridazine ring. Attempts at oxidation of the dihydropyridazine ring with PIFA and MnO2, resulted in the formation of 5- and 5,6-dihydroxy-phthalazine derivatives. The oxidation of the dihydropyfidazine ring was achieved by way of photooxygenation. The phthalazine type dihydrodiol is unstable and easily undergoes aromatization. The Diels-Alder reaction of tetrazine with cyclohexadiene acetonide and epoxy-ketal cyclohexene as a dienophile was investigated. These reactions led to the possible carcinogenic phthalazine Type of dihydrodiol and diol epoxide where the hydroxyl groups are protected. (C) 2004 Elsevier Ltd. All rights reserved.
Atıf için künye
Özer, G., Saracoglu, N., MENZEK, A., & BALCI, M. (2005). Synthesis of the possible carcinogenic dihydrodiol and diol epoxide of phthalazine. TETRAHEDRON, 61(6), 1545–1550. https://doi.org/10.1016/j.tet.2004.11.071
BibTeX
@article{ozer2005-334672,
author = {Özer, Galip and Saracoglu, Nurullah and MENZEK, Abdullah and BALCI, METİN},
title = {Synthesis of the possible carcinogenic dihydrodiol and diol epoxide of phthalazine},
journal = {TETRAHEDRON},
year = {2005},
volume = {61},
number = {6},
pages = {1545--1550},
issn = {0040-4020},
doi = {10.1016/j.tet.2004.11.071},
url = {https://akademik.atauni.edu.tr/yayinlar/334672-synthesis-of-the-possible-carcinogenic-dihydrodiol-and-diol-epoxide-of}
}