Effect of glimepiride on paraoxonase activity
Özet
In this study, the effect of glimepiride on serum paraoxonase activity (EC 3.1.8.1.) has been investigated in vitro . The inhibition and activation effects of this drug on serum paraoxonase activity was measured spectrophotometrically using paraoxon as the substrate. The phenotypic distribution of paraoxonase was determined using the dual substrate paraoxon and phenyl acetate as substrates. It was observed that glimepiride inhibited serum paraoxonase activity. In addition, an in vivo study was performed for glimepiride in Sprague-Dawley rats. It was demonstrated that paraoxonase in serum, liver, and heart of Sprague-Dawley rat was significantly inhibited.
Atıf için künye
Demir, Y., Nadaroğlu, H., & Demir, N. (2006). Effect of glimepiride on paraoxonase activity. Pharmaceutical biology, 44(5), 396–399. https://doi.org/10.1080/13880200600751717
BibTeX
@article{demir2006-330245,
author = {Demir, Y and Nadaroğlu, Hayrunnisa and Demir, N},
title = {Effect of glimepiride on paraoxonase activity},
journal = {Pharmaceutical biology},
year = {2006},
volume = {44},
number = {5},
pages = {396--399},
issn = {1388-0209},
doi = {10.1080/13880200600751717},
url = {https://akademik.atauni.edu.tr/yayinlar/330245-effect-of-glimepiride-on-paraoxonase-activity}
}