Bacteria Derived Anticancer Molecules
Özet
Cancer is the second most common cause of death worldwide. Lung, colorectal, prostate and breast
cancer are the most diagnosed forms of this disease. Most of the drugs used or currently tested in
cancer treatments are derived from plants, bacteria or fungi. Bacteria are one of the most important
sources of natural products of medical and biotechnological importance. Bacteria produce enzymes,
bacteriocins, toxins, and antibiotics, which are protein or peptide and have anticancer properties. To
important anticancer enzymes originating from bacteria; asparaginase and arginine deaminase to
bacteriocins; colicin, bovicin, nisin, pediocin, plantaricin, pyosin and microsin E492 to toxins;
diphtheria toxin, exo-toxin A, botulinum toxin and antibiotics; Actinomycin D, bleomycin,
doxorubicin and mitomycin C can be given as examples. For example, it has been reported that
asparaginase from Escherichia coli for treatment of acute lymphoblastic leukemia; microscin E492
from Klebsiella pneumoniae for treatment of leukemia, cervical and colon cancer; pediocin PA-1 from
Pediococcus acidilactici for treatment of lung and colon cancer; bleomycin from Streptomyces
verticillus for the treatment of Hodgink lymphoma, testicular and ovarian cancer; doxorubisin from
Streptomyces peucetius for treatment of breast, neuroblastoma, ovary, lymphoma, leukemia, stomach
and thyroid cancers can be used. Bacteria also produce non-ribosomal peptides such as arenamide,
ariachemycin, halolitoralin, lajollamycin, lusentamycin, mechercharmycin A, mixirin, padanamide,
piperazimycin, proximycin, urukthapelstatin and halolitoralin, which have anticancer activity like
other proteins or peptides. Arenamide from Salinispora arenicola against colon cancer; halolitoral
from Halobacillus litoralis against stomach cancer; proximycin from Verrucosispora sp against
stomach and breast cancer and urukthapelstatin from Mechercharimyces assporophorigenens against
lung and ovarian cancers may be used as drugs.
Key words: bacterium, anticancer, biological activity
Sürdürülebilir Kalkınma Amaçları
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SKA 3: Sağlıklı Bireyler
Atıf için künye
Doymuş Yılmaz, M., Arslan, N. P., & Çınar Yılmaz, H. (2022). Bacteria Derived Anticancer Molecules. International ICONTECH CONFERENCE-5, Şanlıurfa (ss. 182–189).
BibTeX
@inproceedings{doymusyilmaz2022-293896,
author = {Doymuş Yılmaz, Meryem and Arslan, Nazlı Pınar and Çınar Yılmaz, Handan},
title = {Bacteria Derived Anticancer Molecules},
booktitle = {International ICONTECH CONFERENCE-5},
address = {Şanlıurfa},
year = {2022},
pages = {182--189},
url = {https://akademik.atauni.edu.tr/yayinlar/293896-bacteria-derived-anticancer-molecules}
}