α-tocopherol ameliorates copper II oxide nanoparticles-induced cytotoxic, biochemical, apoptotic, and genotoxic damages in the rainbow trout gonad cells-2 (RTG-2) culture
Özet
We investigated the effects of α-tocopherol on oxidative stress-caused damage caused by copper II oxide nanoparticles (CuO NPs) on Oncorhynchus mykiss gonadal cells (RTG-2) for 24 and 48 h. α-Tocopherol reversed the cell death and alterations in the expressions of genes such as sod1, gpx1a, gpx4b, and igf2 caused by CuO NPs; it also supported the expressions of cat, igf1, and gapdh genes caused by CuO NPs for 24 h and promoted alterations in the expressions of the sod2, gh1, and igf1
genes for 48 h. Additionally, α-tocopherol reversed the caspase 3/7
activity increased by CuO NPs for 24 h and supported it’s decrease for
48 h. α-Tocopherol supported the increase in tail DNA (%) affected by
CuO NPs for 24 h and reversed it for 48 h. Therefore, α-tocopherol may
have the potential to protect against cellular alterations induced by
CuO NPs in a time-dependent manner.
Atıf için künye
Çiçek, S. (2023). α-tocopherol ameliorates copper II oxide nanoparticles-induced cytotoxic, biochemical, apoptotic, and genotoxic damages in the rainbow trout gonad cells-2 (RTG-2) culture. ENVIRONMENTAL TOXICOLOGY AND PHARMACOLOGY, 101(2023), 1–10. https://doi.org/10.1016/j.etap.2023.104168
BibTeX
@article{cicek2023-290193,
author = {Çiçek, Semra},
title = {α-tocopherol ameliorates copper II oxide nanoparticles-induced cytotoxic, biochemical, apoptotic, and genotoxic damages in the rainbow trout gonad cells-2 (RTG-2) culture},
journal = {ENVIRONMENTAL TOXICOLOGY AND PHARMACOLOGY},
year = {2023},
volume = {101},
number = {2023},
pages = {1--10},
issn = {1382-6689},
doi = {10.1016/j.etap.2023.104168},
url = {https://akademik.atauni.edu.tr/yayinlar/290193-a-tocopherol-ameliorates-copper-ii-oxide-nanoparticles-induced-cytotoxic}
}