Toxicity of Norbornanetetraacetate, Cyclooctanetetraacetate, and 7-oxanorbornene derivative against the stored pest Sitophilus granarius (L.).

The chemical compounds norbornanetetraacetate (1b),

cyclooctane-1,2,5,6-tetraacetate (2b), and lactone 3 showed

fumigant toxicity against adults of Sitophilus granarius

(Coleoptera: Curculionidae). The P-value tests were carried

out to determine the statistical significance of dose and time

combinations against the insect. Norbornanetetraacetate (1b)

was the most toxic of the three compounds tested in 3 μL

(1 μL/L air) within the first 24 h after application. The same

level of toxicity was obtained with cyclooctane-1,2,5,6-tetraacetate

(2b) in 3 μL at 48 h. On the other hand, lactone

3 was the most toxic of the three compounds tested in 3 μL

(1 μL/L air) at 72 h. In 9 μL (3 μL/L air), norbornanetetraacetate

(1b) was the most toxic of the three compounds

tested on adult S. granarius up to 48 h. Norbornanetetraacetate

(1b) was more toxic than lactone 3 and cyclooctane-

1,2,5,6-tetraacetate (2b) at 6-48 h in 9 μL (3 μL/L air),

and as toxic as lactone 3 at 72 h. In general, norbornanetetraacetate

(1b) is more toxic than cyclooctane-1,2, 5,6-

tetraacetate (2b) and lactone 3 at all doses and exposure

times against adult S. granarius.