Investigation of the Effect of Asprosin Level on Fertility Success and Oxidative Stress in Simmental Cows

Asprosin, a protein hormone that regulates hunger and glucose homeostasis, is produced by white adipose tissue. The aim of this study was to investigate the effect of asprosin level on fertility and oxidative stress parameters in Simmental cows. In the study, 44 Simmental multiparous cows were used. PRID was used to synchronise the animals. Blood samples were obtained from the cattle on the day of artificial insemination, and the amount of asprosin was measured. Animals were divided into two groups: a low asprosin (LA) group and a high asprosin (HA) group. On day 25, blood samples were taken, and pregnancy-associated glycoprotein (PAG2), total antioxidant level (TAS) and total oxidant level (TOS) were measured using commercial kits. Ultrasonography was used to diagnose pregnancy on day 45. The TAS level at day 25 was higher in the HA group than the TAS level at the beginning of the study (p = 0.007). The TOS level at the beginning of the study was higher in the HA group than in the LA group (p = 0.017). The TOS level of cows in the LA group on day 25 was significantly higher than the TOS level at the beginning of the study (p = 0.028). In conclusion, asprosin levels in cows affected oxidative stress parameters. According to receiver operating characteristic curve (ROC) analysis, there was a strong correlation between TOS and asprosin, and it was concluded that cows with HA values may be exposed to oxidative stress.