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Carnosic Acid Ameliorates Indomethacin-Induced Gastric Ulceration in Rats by Alleviating Oxidative Stress and Inflammation

Betül DANIŞMAN, BETÜL ÇİÇEK, Serkan Yıldırım, İsmail BOLAT, DENİZ KANTAR GÜL, Kirill S. Golokhvast, Dragana Nikitovic, Aristidis Tsatsakis, ALI TAGHIZADEHGHALEHJOUGHI

Biomedicines Cilt 11 · Sayı 3 · 01.03.2023
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Özet

Nonsteroidal anti-inflammatory drugs (NSAIDs) such as aspirin and indomethacin (IND) are the most commonly prescribed for inflammation or pain. However, widespread use causes several adverse effects, such as gastric ulcers, upper gastric system bleeding, and erosions. Carnosic acid (CA) is an important natural antioxidant found in rosemary (Rosmarinus essentials) and exhibits a protective effect by suppressing oxidative stress and inflammation. This study aimed to investigate the impact of CA on IND-induced gastric ulceration. Wistar male rats received CA (100 mg/kg) or esomeprazole (ESP) (20 mg/kg, standard drug) by oral gavage for 14 days, after that gastric ulceration was induced by oral administration of 100 mg/kg IND. CA pretreatment attenuated both gross morphological lesions and histopathological alterations. CA strongly reduced IND-induced oxidative stress, verified by a decrease in MDA (p < 0.001) and TOS levels (p < 0.05). Furthermore, an IND-dependent increase in CAT (p < 0.001) and GPx (p < 0.01) activities, as well as a reduction in GSH levels (p < 0.01), were ameliorated by CA pretreatment. CA also attenuated inflammatory damage by suppressing IL-1 beta (p < 0.01), IL-6 (p < 0.01), and TNF alpha (p < 0.001) production and increasing Nrf2/HO-1 (p < 0.05) expressions. In conclusion, CA shows a gastroprotective effect by reducing oxidative stress and attenuating inflammation.

Anahtar kelimeler

oxidative stress RISK INFLAMMATION toxicity antioxidant capacity SAGE Indomethacin gastric ulcer carnosic acid PROTON-PUMP INHIBITORS LONG-TERM USE DITERPENES

Atıf için künye

DANIŞMAN, B., ÇİÇEK, B., Yıldırım, S., BOLAT, İ., KANTAR GÜL, D., Golokhvast, K. S., Nikitovic, D., Tsatsakis, A., & TAGHIZADEHGHALEHJOUGHI, A. (2023). Carnosic Acid Ameliorates Indomethacin-Induced Gastric Ulceration in Rats by Alleviating Oxidative Stress and Inflammation. Biomedicines, 11(3). https://doi.org/10.3390/biomedicines11030829

BibTeX 
@article{danisman2023-259312,
  author = {DANIŞMAN, Betül and ÇİÇEK, BETÜL and Yıldırım, Serkan and BOLAT, İsmail and KANTAR GÜL, DENİZ and Golokhvast, Kirill S. and Nikitovic, Dragana and Tsatsakis, Aristidis and TAGHIZADEHGHALEHJOUGHI, ALI},
  title = {Carnosic Acid Ameliorates Indomethacin-Induced Gastric Ulceration in Rats by Alleviating Oxidative Stress and Inflammation},
  journal = {Biomedicines},
  year = {2023},
  volume = {11},
  number = {3},
  issn = {2227-9059},
  doi = {10.3390/biomedicines11030829},
  url = {https://akademik.atauni.edu.tr/yayinlar/259312-carnosic-acid-ameliorates-indomethacin-induced-gastric-ulceration-in-rats-by}
}