Makale
Tam Makale
Uluslararası
2018
Effects of the Phosphodiesterase-5 (PDE-5) Inhibitors, Avanafil and Zaprinast, on Bone Remodeling and Oxidative Damage in a Rat Model of Glucocorticoid-Induced Osteoporosis
MEDICAL SCIENCE MONITOR BASIC RESEARCH
Cilt 24 · ss. 47–58 · 01.01.2018
Özet
Background: The aim of this study was to evaluate the effects of the phosphodiesterase-5 (PDE-5) inhibitors, zaprinast and avanafil, on NO signalling pathway, bone mineral density (BMD), epiphyseal bone width, bone marrow angiogenesis, and parameters of oxidative stress in a rat model of glucocorticoid-induced osteoporosis (GIOP).
Anahtar kelimeler
stress
osteoporosis
NITRIC-OXIDE
EXPRESSION
MINERAL DENSITY
bone density
ANTIOXIDANT ACTIVITY
SUSCEPTIBILITY
DNA-DAMAGE
ovariectomy
METABOLISM
dexamethasone
PHOSPHODIESTERASE-5 INHIBITORS
COENZYME Q(10)
Atıf için künye
Huyut, Z., BAKAN, N., Yıldırım, S., & Alp, H. H. (2018). Effects of the Phosphodiesterase-5 (PDE-5) Inhibitors, Avanafil and Zaprinast, on Bone Remodeling and Oxidative Damage in a Rat Model of Glucocorticoid-Induced Osteoporosis. MEDICAL SCIENCE MONITOR BASIC RESEARCH, 24, 47–58. https://doi.org/10.12659/msmbr.908504
BibTeX
@article{huyut2018-259304,
author = {Huyut, Zübeyir and BAKAN, Nuri and Yıldırım, Serkan and Alp, Hamit Hakan},
title = {Effects of the Phosphodiesterase-5 (PDE-5) Inhibitors, Avanafil and Zaprinast, on Bone Remodeling and Oxidative Damage in a Rat Model of Glucocorticoid-Induced Osteoporosis},
journal = {MEDICAL SCIENCE MONITOR BASIC RESEARCH},
year = {2018},
volume = {24},
pages = {47--58},
issn = {2325-4416},
doi = {10.12659/msmbr.908504},
url = {https://akademik.atauni.edu.tr/yayinlar/259304-effects-of-the-phosphodiesterase-5-pde-5-inhibitors-avanafil-and-zaprinast-on}
}