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Zingerone attenuates vancomycin-induced hepatotoxicity in rats through regulation of oxidative stress, inflammation and apoptosis

Sefa Küçükler, Ekrem Darendelioglu, Serkan Yıldırım, Adnan Ayna, Serkan Yıldırım, Fatih Mehmet Kandemir

Life sciences Cilt 259 · 01.10.2020
DOI ile aç

Özet

Aim: Vancomycin (VCM) is a glycopeptide antibiotic widely used to treat serious infections caused by methi-cillin-resistant Staphylococcus aureus and has been associated with some severe side effects such as hepatotoxicity and nephrotoxicity. However, the underlying mechanism of VCM-induced hepatotoxicity is not yet fully understood. Therefore, the current study was designed to evaluate the protective effects of zingerone (Zin) against VCM-induced hepatotoxicity in rats.

Anahtar kelimeler

oxidative stress IN-VITRO INFLAMMATION CELLS cytokines ASSAY antioxidant apoptosis nephrotoxicity hepatotoxicity PROTECTS Vancomycin Zingerone

Atıf için künye

Küçükler, S., Darendelioglu, E., Yıldırım, S., Ayna, A., Yıldırım, S., & Kandemir, F. M. (2020). Zingerone attenuates vancomycin-induced hepatotoxicity in rats through regulation of oxidative stress, inflammation and apoptosis. Life sciences, 259. https://doi.org/10.1016/j.lfs.2020.118382

BibTeX 
@article{kucukler2020-259203,
  author = {Küçükler, Sefa and Darendelioglu, Ekrem and Yıldırım, Serkan and Ayna, Adnan and Yıldırım, Serkan and Kandemir, Fatih Mehmet},
  title = {Zingerone attenuates vancomycin-induced hepatotoxicity in rats through regulation of oxidative stress, inflammation and apoptosis},
  journal = {Life sciences},
  year = {2020},
  volume = {259},
  issn = {0024-3205},
  doi = {10.1016/j.lfs.2020.118382},
  url = {https://akademik.atauni.edu.tr/yayinlar/259203-zingerone-attenuates-vancomycin-induced-hepatotoxicity-in-rats-through}
}