The protective effects of epigallocatechin gallate on lipopolysa ccharide-induced hepatotoxicity: an in vitro study on Hep3B cells

Karamese, Murat; Guvendi, Bulent; Karamese, Selina Aksak; CINAR, Irfan; Can, Serpil; Erol, Hüseyin Serkan; Aydın, Hakan; Gelen, Volkan; Karakus, Emre

Makale Tam Makale Uluslararası 2016

The protective effects of epigallocatechin gallate on lipopolysa ccharide-induced hepatotoxicity: an in vitro study on Hep3B cells

Murat Karamese, Bulent Guvendi, Selina Aksak Karamese, Irfan CINAR, Serpil Can, Hüseyin Serkan Erol, Hakan Aydın, Volkan Gelen, Emre Karakus

IRANIAN JOURNAL OF BASIC MEDICAL SCIENCES Cilt 19 · Sayı 5 · ss. 483–489 · 01.05.2016

Özet

Objective(s): In the present study, our aim was to investigate the possible protective effects of epigallocatechin gallate (EGCG) on lipopolysaccharide (LPS)-induced hepatotoxicity by using Hep3B human hepatoma cells. Specifically, the study examines the role of some proinflammatory markers and oxidative damage as possible mechanisms of LPS-associated cytotoxicity. Consequently, the hepatocellular carcinoma cell line Hep3B was chosen as a model for investigation of LPS toxicity and the effect of EGCG on LPS-exposed cells.

Anahtar kelimeler

oxidative stress cytokines ANTIOXIDANT ENZYMES MECHANISMS LIPOPOLYSACCHARIDE Interleukin-6 (-)-epigallocatechin-3-gallate RAT-LIVER Epigallocatechin gallate Acute liver failure Hep3B GREEN TEA POLYPHENOL HUMAN HEPATOCYTES HEPG2 CELLS

Atıf için künye

Karamese, M., Guvendi, B., Karamese, S. A., CINAR, I., Can, S., Erol, H. S., Aydın, H., Gelen, V., & Karakus, E. (2016). The protective effects of epigallocatechin gallate on lipopolysa ccharide-induced hepatotoxicity: an in vitro study on Hep3B cells. IRANIAN JOURNAL OF BASIC MEDICAL SCIENCES, 19(5), 483–489.

BibTeX

@article{karamese2016-255718,
  author = {Karamese, Murat and Guvendi, Bulent and Karamese, Selina Aksak and CINAR, Irfan and Can, Serpil and Erol, Hüseyin Serkan and Aydın, Hakan and Gelen, Volkan and Karakus, Emre},
  title = {The protective effects of epigallocatechin gallate on lipopolysa ccharide-induced hepatotoxicity: an in vitro study on Hep3B cells},
  journal = {IRANIAN JOURNAL OF BASIC MEDICAL SCIENCES},
  year = {2016},
  volume = {19},
  number = {5},
  pages = {483--489},
  issn = {2008-3866},
  url = {https://akademik.atauni.edu.tr/yayinlar/255718-the-protective-effects-of-epigallocatechin-gallate-on-lipopolysa-ccharide}
}