Astaxanthin alleviates renal damage of rats on high fructose diet through modulating NF kappa B/SIRT1 pathway and mitigating oxidative stress

İskender, Hatice; Yenice, Güler; Dokumacıoğlu, Eda; Hayırlı, Armağan; Sevim, Çiğdem; Dokumacioglu, Ali; Terim Kapakin, Kübra Asena

doi:10.1080/13813455.2018.1493609

Makale Tam Makale Uluslararası 2020

Astaxanthin alleviates renal damage of rats on high fructose diet through modulating NF kappa B/SIRT1 pathway and mitigating oxidative stress

Hatice İskender, Güler Yenice, Eda Dokumacıoğlu, Armağan Hayırlı, Çiğdem Sevim, Ali Dokumacioglu, Kübra Asena Terim Kapakin

ARCHIVES OF PHYSIOLOGY AND BIOCHEMISTRY Cilt 126 · Sayı 1 · ss. 89–93 · 01.01.2020

DOI ile aç

Özet

This study was conducted to determine the effect of astaxanthin (ASX) treatment on alleviation of renal damage in high fructose induced nephrotoxicity in rats. Treatments were arranged in a 2 x 2 factorial fashion: administrations of fructose (30%, via drinking water) and ASX (1 mg/kg/day, within 0.2 ml olive oil) for 8 weeks. Data were analyzed by two-way ANOVA. The ASX treatment decreased serum urea (p < .01) and blood urea-N concentrations (p < .02) at a lower extent in rats receiving fructose than those not receiving fructose. Moreover, the ASX treatment reversed the increases in malondialdehyde (MDA) (p < .0001) and nuclear factor kappa B (NF-kappa B) (p < .0003) levels and the decreases in superoxide dismutase (SOD) activity (p < .0001) and sirtuin-1 (SIRT1) level (p < .0004), in the kidney upon high fructose consumption. The data suggest that ASX supplementation alleviates renal damage induced by high fructose consumption through modulating NF-kappa B/SIRT1 pathway and mitigating oxidative stress.

Anahtar kelimeler

PATHOGENESIS hypertension oxidative stress IN-VITRO INFLAMMATION Activation ANTIOXIDANTS NF-KAPPA-B PROTEIN Astaxanthin Acetylation SIRT1 fructose

Atıf için künye

İskender, H., Yenice, G., Dokumacıoğlu, E., Hayırlı, A., Sevim, Ç., Dokumacioglu, A., & Terim Kapakin, K. A. (2020). Astaxanthin alleviates renal damage of rats on high fructose diet through modulating NF kappa B/SIRT1 pathway and mitigating oxidative stress. ARCHIVES OF PHYSIOLOGY AND BIOCHEMISTRY, 126(1), 89–93. https://doi.org/10.1080/13813455.2018.1493609

BibTeX

@article{iskender2020-255314,
  author = {İskender, Hatice and Yenice, Güler and Dokumacıoğlu, Eda and Hayırlı, Armağan and Sevim, Çiğdem and Dokumacioglu, Ali and Terim Kapakin, Kübra Asena},
  title = {Astaxanthin alleviates renal damage of rats on high fructose diet through modulating NF kappa B/SIRT1 pathway and mitigating oxidative stress},
  journal = {ARCHIVES OF PHYSIOLOGY AND BIOCHEMISTRY},
  year = {2020},
  volume = {126},
  number = {1},
  pages = {89--93},
  issn = {1381-3455},
  doi = {10.1080/13813455.2018.1493609},
  url = {https://akademik.atauni.edu.tr/yayinlar/255314-astaxanthin-alleviates-renal-damage-of-rats-on-high-fructose-diet-through}
}