Global phylogeography and genetic diversity of the zoonotic tapeworm Echinococcus granulosus sensu stricto genotype G1
Özet
Echinococcus granulosus sensu stricto (s.s.) is the major cause of human cystic echinococcosis worldwide and is listed among the most severe parasitic diseases of humans. To date, numerous studies have investigated the genetic diversity and population structure of E. granulosus s.s. in various geographic regions. However, there has been no global study. Recently, using mitochondrial DNA, it was shown that E. granulosus s.s. G1 and G3 are distinct genotypes, but a larger dataset is required to confirm the distinction of these genotypes. The objectives of this study were to: (i) investigate the distinction of genotypes G1 and G3 using a large global dataset; and (ii) analyse the genetic diversity and phylogeography of genotype G1 on a global scale using near-complete mitogenome sequences. For this study, 222 globally distributed E. granulosus s.s. samples were used, of which 212 belonged to genotype G1 and 10 to G3. Using a total sequence length of 11,682bp, we inferred phylogenetic networks for three datasets: E. granulosus s.s. (n222), G1 (n212) and human G1 samples (n41). In addition, the Bayesian phylogenetic and phylogeographic analyses were performed. The latter yielded several strongly supported diffusion routes of genotype G1 originating from Turkey, Tunisia and Argentina. We conclude that: (i) using a considerably larger dataset than employed previously, E. granulosus s.s. G1 and G3 are indeed distinct mitochondrial genotypes; (ii) the genetic diversity of E. granulosus s.s. G1 is high globally, with lower values in South America; and (iii) the complex phylogeographic patterns emerging from the phylogenetic and geographic analyses suggest that the current distribution of genotype G1 has been shaped by intensive animal trade. (C)
Anahtar kelimeler
Sürdürülebilir Kalkınma Amaçları
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SKA 3: Sağlıklı Bireyler
Atıf için künye
KİNKAR, L., LAURİMAE, T., Acosta-Jamett, G., ANDRESİUK, V., Balkaya, İ., CASULLİ, A., Gasser, R. B., VAN DER GIESSEN, J., MİGUEL GONZALEZ, L., Haag, K. L., Zait, H., IRSHADULLAH, M., JABBAR, A., Jenkins, D. J., KIA, E. B., MANFREDİ, M. T., MIRHENDI, H., M'rad, S., Rostami-Nejad, M., … SAARMA, U. (2018). Global phylogeography and genetic diversity of the zoonotic tapeworm Echinococcus granulosus sensu stricto genotype G1. INTERNATIONAL JOURNAL FOR PARASITOLOGY, 48, 729–742. https://doi.org/10.1016/j.ijpara.2018.03.006
BibTeX
@article{kinkar2018-255136,
author = {KİNKAR, Liina and LAURİMAE, Teivi and Acosta-Jamett, Gerardo and ANDRESİUK, Vanessa and Balkaya, İbrahim and CASULLİ, Adriano and Gasser, Robin B. and VAN DER GIESSEN, Joke and MİGUEL GONZALEZ, Luis and Haag, Karen L. and Zait, Houria and IRSHADULLAH, Malik and JABBAR, Abdul and Jenkins, David J. and KIA, Eshrat Beigom and MANFREDİ, Maria Teresa and MIRHENDI, Hossein and M'rad, Selim and Rostami-Nejad, Mohammad and Oudni-M'rad, Myriam and BEATRIZ PIERANGELI, Nora and Ponce-Gordo, Francisco and Rehbein, Steffen and Sharbatkhori, Mitra and ŞIMSEK, Sami and Viviana Soriano, Silvia and SPRONG, Hein and SNABEL, Viliam and UMHANG, Gerald and Varcasia, Antonio and SAARMA, Urmas},
title = {Global phylogeography and genetic diversity of the zoonotic tapeworm Echinococcus granulosus sensu stricto genotype G1},
journal = {INTERNATIONAL JOURNAL FOR PARASITOLOGY},
year = {2018},
volume = {48},
pages = {729--742},
issn = {0020-7519},
doi = {10.1016/j.ijpara.2018.03.006},
url = {https://akademik.atauni.edu.tr/yayinlar/255136-global-phylogeography-and-genetic-diversity-of-the-zoonotic-tapeworm}
}