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Makale Tam Makale Uluslararası 2018

Genetic diversity and phylogeography of the elusive, but epidemiologically important Echinococcus granulosus sensu stricto genotype G3

Liina KİNKAR, Teivi LAURİMAE, İbrahim Balkaya, Adriano CASULLİ, Houria ZAİT, Malik Irshadullah, Mitra SHARBATKHORI, Hossein MIRHENDI, Mohammad Rostami-Nejad, Francisco Ponce-Gordo, Steffen REHBEİN, Eshrat Beigom KIA, Sami Simsek, Viliam SNABEL, Gerald UMHANG, Antonio VARCASİA, Urmas SAARMA

PARASITOLOGY Cilt 145 · Sayı 12 · ss. 1613–1622 · 01.10.2018
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Özet

Cystic echinococcosis (CE) is a severe parasitic disease caused by the species complex Echinococcus granulosus sensu lato. Human infections are most commonly associated with E. granulosus sensu stricto (s.s.), comprising genotypes G1 and G3. The objective of the current study was to provide first insight into the genetic diversity and phylogeography of genotype G3. Despite the epidemiological importance of the genotype, it has remained poorly explored due to the ambiguity in the definition of the genotype. However, it was recently demonstrated that long sequences of mitochondrial DNA (mtDNA) provide a reliable method to discriminate G1 and G3 from each other. Therefore, we sequenced near-complete mtDNA of 39 G3 samples, covering most of the known distribution range and host spectra of the genotype. The phylogenetic network revealed high genetic variation within E. granulosus s.s. G3 and while G3 is significantly less prevalent worldwide than G1, the genetic diversity of both of the genotypes is equally high. We also present the results of the Bayesian phylogeographic analysis, which yielded several well-supported diffusion routes of genotype G3 originating from Turkey and Iran, suggesting the Middle East as the origin of the genotype.

Anahtar kelimeler

mitochondrial DNA SHEEP MOLECULAR CHARACTERIZATION PHYLOGEOGRAPHY Cystic echinococcosis echinococcus granulosus ZOONOSES CESTODA TAENIIDAE PHYLOGENETIC-RELATIONSHIPS CERVID STRAIN Bayesian phylogeny genotype G3 genetic variability mitochondrial genome BROWN BEARS URSUS-ARCTOS G1

Sürdürülebilir Kalkınma Amaçları

  • SKA 3: Sağlıklı Bireyler

Atıf için künye

KİNKAR, L., LAURİMAE, T., Balkaya, İ., CASULLİ, A., ZAİT, H., Irshadullah, M., SHARBATKHORI, M., MIRHENDI, H., Rostami-Nejad, M., Ponce-Gordo, F., REHBEİN, S., KIA, E. B., Simsek, S., SNABEL, V., UMHANG, G., VARCASİA, A., & SAARMA, U. (2018). Genetic diversity and phylogeography of the elusive, but epidemiologically important Echinococcus granulosus sensu stricto genotype G3. PARASITOLOGY, 145(12), 1613–1622. https://doi.org/10.1017/s0031182018000549

BibTeX 
@article{kinkar2018-255126,
  author = {KİNKAR, Liina and LAURİMAE, Teivi and Balkaya, İbrahim and CASULLİ, Adriano and ZAİT, Houria and Irshadullah, Malik and SHARBATKHORI, Mitra and MIRHENDI, Hossein and Rostami-Nejad, Mohammad and Ponce-Gordo, Francisco and REHBEİN, Steffen and KIA, Eshrat Beigom and Simsek, Sami and SNABEL, Viliam and UMHANG, Gerald and VARCASİA, Antonio and SAARMA, Urmas},
  title = {Genetic diversity and phylogeography of the elusive, but epidemiologically important Echinococcus granulosus sensu stricto genotype G3},
  journal = {PARASITOLOGY},
  year = {2018},
  volume = {145},
  number = {12},
  pages = {1613--1622},
  issn = {0031-1820},
  doi = {10.1017/s0031182018000549},
  url = {https://akademik.atauni.edu.tr/yayinlar/255126-genetic-diversity-and-phylogeography-of-the-elusive-but-epidemiologically}
}