Rutin Attenuates Gentamicin Induced Renal Damage By Reducing The Oxidative Stress Inflammation Apoptosis And Autophagy In Rats
Özet
Abstract
The aim of this study was to evaluate the effect of rutin on oxidative stress, inflammation, apoptosis, and
autophagy in gentamicin-induced nephrotoxicity in rats. The administration of gentamicin at a dose of 80
mg/kg/d for 8 days intraperitoneally induced nephrotoxicity as evidenced by increased serum urea and creatinine
levels, and histopathology. Rutin treatment 6 days before gentamicin administration and co-treatment with
gentamicin for 8 days in gentamicin + rutin group attenuated nephrotoxicity induced by gentamicin by reducing
serum urea, creatinine, malondialdehyde (MDA), increasing superoxide dismutase (SOD), catalase (CAT),
glutathione peroxidase (GPx) activities and reduced glutathione (GSH) content, and inhibiting the inducible
nitric oxide synthase (iNOS), cleaved caspase 3, and light chain 3B (LC3B) expression as evidenced by
immunohistochemical staining. The present study demonstrated that rutin has anti-oxidant, anti-inflammatory,
antiapoptotic, antiautophagic effects, and that rutin treatment could attenuate gentamicin-induced nephrotoxicity.
Keywords: Gentamicin, Rutin, Nephrotoxicity, Oxidative stress, Apoptosis, Autophagy.
Atıf için künye
Kandemir, F. M., Özkaraca, M., Apaydın Yıldırım, B., Hanedan, B., Aktaş Şenocak, E., & Benzer, F. (2014). Rutin Attenuates Gentamicin Induced Renal Damage By Reducing The Oxidative Stress Inflammation Apoptosis And Autophagy In Rats. International Scientific Congress, Scientific Papers Veterinary Medicine, Iasi (ss. 43).
BibTeX
@inproceedings{kandemir2014-254231,
author = {Kandemir, Fatih Mehmet and Özkaraca, Mustafa and Apaydın Yıldırım, Betül and Hanedan, Başak and Aktaş Şenocak, Esra and Benzer, Fulya},
title = {Rutin Attenuates Gentamicin Induced Renal Damage By Reducing The Oxidative Stress Inflammation Apoptosis And Autophagy In Rats},
booktitle = {International Scientific Congress, Scientific Papers Veterinary Medicine},
address = {Iasi},
year = {2014},
pages = {43},
url = {https://akademik.atauni.edu.tr/yayinlar/254231-rutin-attenuates-gentamicin-induced-renal-damage-by-reducing-the-oxidative}
}