Effect of Some Immunomodulators Use Together with PPR Vaccine on Immune system in Morkaraman Sheep

In this study, it was aimed to show the effects of vitamin C (Vit-C), vitamin D (Vit-D), levamisole (LMS), inactivated parapoxvirus ovis (iPPVO) and corynebacterium cutis lysate (CCL) on the immune system in Mor-karaman sheep on which the peste des petitis ruminant (PPR) vaccine was administered. In the Group B (Vit-D + PPR vaccine), in terms of IgG, when compared 0th (1.27±0.15), 14th ( 1.08±.0.21), 21st (1.23±0.23) and 28th (1.26±0.42), the values of the day 7th (1.68±0.24) were determined to be significantly higher (P<0.01). In comparison to overall evaluation based on groups of IgG assay, the Group C (LMS + PPR vaccine) value (1.79±1.18) was determined to be significantly higher than the Group F (PPR vaccine) (1.21±0.43), Group A (Vit-C + PPR vaccine) (1.27±0.51), Group B (1.31±0.33) and Group D (iPPVO + PPR vaccine) values (1.38±0.48) (P<0.01). In terms of IgM, when days among groups are compared, the highest value was determined on the 7th day in the Group A (0.50±0.13) and this value was determined to be significant according to the 7th day Group F (0.28±0.11), Group E (CCL + A value (0.45±0.15) was determined to be significantly higher than the Group D (0.33±0.14), Group E (0.34±0.19), Group F values (0.33±0.22) (P<0.05). In the comparison of group-based general evaluations of globulin values, it was determined that the values obtained in the Group A (4.33±0.55), Group B (4.33±0.48), Group C (4.20±0.50), Group D (4.24±0.33) and Group E (4.29±0.29) groups were significantly higher than the Group F (4.00±0.33) (P<0.01). It was concluded that the application of LMS at the stated dose had positive effects on the immune system due to changes in both IgM and IgG values, and Vit-C application at the stated dose had a partially positive effect only due to changes in IgM value; the administration of Vit-D, iPPVO and CCL at the stated doses did not have any positive effect on the immune system.