Investigation of ischemia-modified albumin and thiol/disulfide homeostasis for the determination of oxidative stress in sheep with toxoplasmosis
Özet
In this study, the aim was to investigate the thiol/disulfide homeostasis (TDH) parameters and ischemia-modified
albumin (IMA) (ABSU) levels to determine oxidative stress in sheep with toxoplasmosis. Twenty-four Morkaraman sheep used in this study were allocated into two groups, one control group and one experimental group.
Each group included 12 sheep. Blood samples were taken from all sheep only once and blood serum levels of
albumin (ALB) (g/L), IMA (ABSU), native thiol (NT) (μmol/L), total thiol (TT) (μmol/L), disulfide (Ds) (μmol/L),
Ds/NT, Ds/TT, NT/TT were investigated. Our results showed that the IMA (ABSU) levels of toxoplasma group
were significantly higher than control group (p < 0.05). However, NT (μmol/L) and TT (μmol/L) level of
toxoplasma group were significantly lower than the control group (p < 0.05). While the oxidant and antioxidant
parameters were positively correlated within themselves, a negative correlation was determined between the
antioxidant and oxidant parameters. In the Receiver Operating Characteristic (ROC) analysis, the area under the
ROC curve (AUC), sensitivity, cut off and specificity values were determined for IMA (ABSU) values. These values
were determined as 0.812, 1.24, 91.7% and 75.0%, respectively. For TT (μmol/L), these values were obtained as
0.750, 330.55, 75.0% and 66.7%. It was concluded that oxidative stress is intensely formed in sheep with
toxoplasmosis, thiol-disulphide homestasis markers, and IMA (ABSU) are valuable markers in determining
oxidative stress in toxoplasmosis.
Atıf için künye
Aydın, Ö., Özkurt, G., Çamkerten, İ., Eren, E., Yanar, K. E., & Aktaş, M. S. (2023). Investigation of ischemia-modified albumin and thiol/disulfide homeostasis for the determination of oxidative stress in sheep with toxoplasmosis. SMALL RUMINANT RESEARCH, 225(107023), 1–6. https://doi.org/10.1016/j.smallrumres.2023.107023
BibTeX
@article{aydin2023-253790,
author = {Aydın, Ömer and Özkurt, Güzin and Çamkerten, İlker and Eren, Emre and Yanar, Kerim Emre and Aktaş, Mustafa Sinan},
title = {Investigation of ischemia-modified albumin and thiol/disulfide homeostasis for the determination of oxidative stress in sheep with toxoplasmosis},
journal = {SMALL RUMINANT RESEARCH},
year = {2023},
volume = {225},
number = {107023},
pages = {1--6},
issn = {0921-4488},
doi = {10.1016/j.smallrumres.2023.107023},
url = {https://akademik.atauni.edu.tr/yayinlar/253790-investigation-of-ischemia-modified-albumin-and-thioldisulfide-homeostasis-for}
}