Acute glufosinate-based herbicide treatment in rats leads to increased ocular interleukin-1β and c-Fos protein levels, as well as intraocular pressure

Çomaklı, Selim; SEVİM, Çiğdem; KONTADAKİS, George; Doğan, Elif; TAGHIZADEHGHALEHJOUGHI, ALI; ÖZKARACA, Mustafa; ASCHNER, Michael; NİKOLOUZAKİS, Taxiarchis Konstantinos; Tsatsakis, Aristides

doi:10.1016/j.toxrep.2019.01.004

Makale Tam Makale Uluslararası 2019

Acute glufosinate-based herbicide treatment in rats leads to increased ocular interleukin-1β and c-Fos protein levels, as well as intraocular pressure

Selim Çomaklı, Çiğdem SEVİM, George KONTADAKİS, Elif Doğan, ALI TAGHIZADEHGHALEHJOUGHI, Mustafa ÖZKARACA, Michael ASCHNER, Taxiarchis Konstantinos NİKOLOUZAKİS, Aristides Tsatsakis

Toxicology Reports Cilt 6 · ss. 155–160 · 01.01.2019

DOI ile aç

Özet

Glufosinate is a common herbicide with neurotoxic effects, leading to seizures, convulsions and memory loss. Glufosinate indirectly induces glutamate toxicity by inhibiting glutamine synthesis in astrocytes. Here, we studied the acute toxic effects of a glufosinate-based herbicide in rat optic nerve at three doses (40, 80 or 120 mu M, equal to 714 or 21 mg/kg bw/day). Serum alanine aminotransferase (ALT), aspartate aminotransferase (AST), urea, glucose, calcium, as well as creatinine concentrations were analyzed after 24, 48 and 72 h treatment. Intraocular pressure (IOP) (expressed as the average of both eyes) was measured with a rebound tonometer. Interleukin-1 beta (IL-1 beta) and c-Fos expression were determined by immunohistochemistry. The results established that the glufosinate-based herbicide significantly increased IL-1 beta and c-Fos immunopositivity in the optic nerve (p < 0.05), concomitant with increased IOP. These results suggest that commercial formulations of glufosinate acutely affect the optic nerve.

Anahtar kelimeler

INFLAMMATION GENE-EXPRESSION BRAIN glutamate C-FOS TRANSCRIPTION ORGANOPHOSPHATE INTRAOCULAR-PRESSURE MESSENGER-RNA Glufosinate NEURONS Interleukin-beta PESTICIDE EXPOSURE JUN

Atıf için künye

Çomaklı, S., SEVİM, Ç., KONTADAKİS, G., Doğan, E., TAGHIZADEHGHALEHJOUGHI, A., ÖZKARACA, M., ASCHNER, M., NİKOLOUZAKİS, T. K., & Tsatsakis, A. (2019). Acute glufosinate-based herbicide treatment in rats leads to increased ocular interleukin-1β and c-Fos protein levels, as well as intraocular pressure. Toxicology Reports, 6, 155–160. https://doi.org/10.1016/j.toxrep.2019.01.004

BibTeX

@article{comakli2019-251110,
  author = {Çomaklı, Selim and SEVİM, Çiğdem and KONTADAKİS, George and Doğan, Elif and TAGHIZADEHGHALEHJOUGHI, ALI and ÖZKARACA, Mustafa and ASCHNER, Michael and NİKOLOUZAKİS, Taxiarchis Konstantinos and Tsatsakis, Aristides},
  title = {Acute glufosinate-based herbicide treatment in rats leads to increased ocular interleukin-1β and c-Fos protein levels, as well as intraocular pressure},
  journal = {Toxicology Reports},
  year = {2019},
  volume = {6},
  pages = {155--160},
  issn = {2214-7500},
  doi = {10.1016/j.toxrep.2019.01.004},
  url = {https://akademik.atauni.edu.tr/yayinlar/251110-acute-glufosinate-based-herbicide-treatment-in-rats-leads-to-increased-ocular}
}