Potential therapeutic role of mesenchymal stem cell in delayed wound healing of diabetic rats
Özet
The aim of the present work was to investigate the effect of BM-MSCs on wound closure in STZ-induced diabetic rats. Diabetic wound models were carried out by making a standard wound on dorsum of forty rats, which were divided into four groups with ten rats in each: Wound from diabetic and non-diabetic control rats were treated with PBS, while diabetic and non-diabetic treated rats were treated with BM-MSCs for 12 days. The closure rate and the ratios relative to the beta actin gene of both treated groups (diabetic and non-diabetic) were significantly increased at 7 and 12 days after wounding as compared to their corresponding controls (P < 0.05). Histologic analysis revealed complete reepithelialization in treated groups. Taken together, BM-MSCs mediated correction of the diabetic wound healing impairment is due to, partly, increased VEGF expression in the skin of STZ-induced diabetic rats.
Anahtar kelimeler
Atıf için künye
Prince, A., Gad, M. A., Hasani, I. W., Warda, M. A. A., & Elbehairy, A. (2016). Potential therapeutic role of mesenchymal stem cell in delayed wound healing of diabetic rats. Der Pharmacia Lettre, 8(15), 62–68. https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=84991709117&origin=inward
BibTeX
@article{prince2016-250717,
author = {Prince, Abdelbary and Gad, Mostafa Abdalla and Hasani, Ibrahim W. and Warda, Mohamad Alı Ahmad and Elbehairy, Adel},
title = {Potential therapeutic role of mesenchymal stem cell in delayed wound healing of diabetic rats},
journal = {Der Pharmacia Lettre},
year = {2016},
volume = {8},
number = {15},
pages = {62--68},
issn = {0975-5071},
url = {https://akademik.atauni.edu.tr/yayinlar/250717-potential-therapeutic-role-of-mesenchymal-stem-cell-in-delayed-wound-healing-of}
}