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Makale Tam Makale Uluslararası 2025

Expansion of Myeloid-Derived Suppressor Cells and Lymphocyte Apoptosis Beyond B-Cell Deficiency in X-Linked Agammaglobulinemia

Ayca Ceylan, Ilknur Kulhas Celik, Sevgi Keles, Figen Celebi Celik, HALİL SAĞLAM, Zeynep Meric, ZEHRA ŞULE HASKOLOĞLU, Mehmet Geyik, Selcen Bozkurt, Nermin Kapci, Saliha Esenboga, Esra Ozek Yucel, Nesrin Gulez, Neslihan Edeer Karaca, Sevgi Bilgic Eltan, Sukru Nail Guner, Cigdem Aydogmus, Tuğba Güler, Mehmet Halil Celiksoy, Esra Karabiber, Ferah Genel, Esin Figen Dogu, Elif Karakoc-aydiner, Deniz Cagdas, Guzide Aksu, Ayca Kiykim, Sara Sebnem Kilic, Ismail Reisli, Kamile Aydan Ikinciogullari, Hasibe Artac

SCANDINAVIAN JOURNAL OF IMMUNOLOGY Cilt 102 · Sayı 5 · 01.11.2025
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Özet

X-linked agammaglobulinemia (XLA) is caused by Bruton tyrosine kinase gene mutations, leading to B-cell deficiency. This study aimed to investigate myeloid-derived suppressor cells (MDSCs) frequency, lymphocyte apoptosis and clinical significance in patients with XLA. The study comprised 46 paediatric (mean age: 9.9 +/- 4.8 years) and 21 adult patients (24.6 +/- 5.9 years). Total MDSCs (HLA-DR(-)CD33(+)CD11b(+)) were subdivided into CD15(+) polymorphonuclear (PMN-MDSCs) and CD14(+) monocytic (M-MDSCs) and analysed by flow cytometry. The paediatric XLA patients had increased M-MDSCs and early apoptotic lymphocyte frequency compared to healthy subjects. The mean diagnostic delay was positively correlated with early apoptotic CD3(+) and CD4(+) T-cells. Seventeen patients (14 adults and 3 children) had bronchiectasis. PMN-MDSCs were higher in adult patients than in paediatric patients. Increased PMN-MDSCs in adults with XLA suggest the presence of chronic inflammation in patients with bronchiectasis. The study findings broaden understanding of XLA's complex immunopathology and highlight the need for more comprehensive immune monitoring of these patients beyond antibody production.

Atıf için künye

Ceylan, A., Kulhas Celik, I., Keles, S., Celebi Celik, F., SAĞLAM, H., Meric, Z., HASKOLOĞLU, Z. Ş., Geyik, M., Bozkurt, S., Kapci, N., Esenboga, S., Ozek Yucel, E., Gulez, N., Edeer Karaca, N., Bilgic Eltan, S., Guner, S. N., Aydogmus, C., Güler, T., Celiksoy, M. H., … Artac, H. (2025). Expansion of Myeloid-Derived Suppressor Cells and Lymphocyte Apoptosis Beyond B-Cell Deficiency in X-Linked Agammaglobulinemia. SCANDINAVIAN JOURNAL OF IMMUNOLOGY, 102(5). https://doi.org/10.1111/sji.70063

BibTeX 
@article{ceylan2025-246846,
  author = {Ceylan, Ayca and Kulhas Celik, Ilknur and Keles, Sevgi and Celebi Celik, Figen and SAĞLAM, HALİL and Meric, Zeynep and HASKOLOĞLU, ZEHRA ŞULE and Geyik, Mehmet and Bozkurt, Selcen and Kapci, Nermin and Esenboga, Saliha and Ozek Yucel, Esra and Gulez, Nesrin and Edeer Karaca, Neslihan and Bilgic Eltan, Sevgi and Guner, Sukru Nail and Aydogmus, Cigdem and Güler, Tuğba and Celiksoy, Mehmet Halil and Karabiber, Esra and Genel, Ferah and Dogu, Esin Figen and Karakoc-aydiner, Elif and Cagdas, Deniz and Aksu, Guzide and Kiykim, Ayca and Kilic, Sara Sebnem and Reisli, Ismail and Ikinciogullari, Kamile Aydan and Artac, Hasibe},
  title = {Expansion of Myeloid-Derived Suppressor Cells and Lymphocyte Apoptosis Beyond B-Cell Deficiency in X-Linked Agammaglobulinemia},
  journal = {SCANDINAVIAN JOURNAL OF IMMUNOLOGY},
  year = {2025},
  volume = {102},
  number = {5},
  issn = {0300-9475},
  doi = {10.1111/sji.70063},
  url = {https://akademik.atauni.edu.tr/yayinlar/246846-expansion-of-myeloid-derived-suppressor-cells-and-lymphocyte-apoptosis-beyond-b}
}