Evaluation of the Correlation between Serum Copeptin Levels Measured in Multi-Trauma Patients and the Stage of Hemorrhagic Shock and Replacement Therapy Need

Objective: This

prospective observational study designed to determine the correlation between

serum copeptin (CPT) quantities measured in patients presenting to the

emergency department with multiple traumas and their hemorrhagic shock stage

and blood-fluid replacement needs.<o:p></o:p>

Methods: Adult

(≥18 years), non-pregnant patients introduced to the emergency department of a

university hospital with multiple traumas between September 2023 and September

2024 were analyzed. A prospective observational and analytical study was

managed. At first admission, CPT levels were measured. Additionally, the

amounts of delivered crystalloids and blood transfusions were listed. Ethics

committee approval was obtained, and participants given informed consent.<o:p></o:p>

Results: Serum CPT

levels were statistically significantly higher in patients with major trauma.

CPT levels increased with the progression of the hemorrhagic shock stage. As

the hemorrhagic shock stage increased, the sum of administered crystalloid

fluids decreased, while the need for blood product transfusion remarkably

increased (p=0.001).<o:p></o:p>

Conclusion: The

findings of the study shoewed a correlation between CPT levels and the severity

of hemorrhagic shock in patients with trauma. Increased CPT levels in the early

phase may designate occult bleeding and assist in risk stratification during

trauma management. CPT appears to be a useful laboratory parameter for

recognize between hemorrhagic shock stages 1 and 2, as well as between stages 1

and 3. It can contribute to clinical evaluation and help guide the need for

blood and blood product monitoring, even in the absence of direct patient

observation.<o:p></o:p>

Keywords:

Copeptin, hemorrhagic shock, trauma, injury severity score, resuscitation,

advanced trauma life support, circulation<o:p></o:p>