ENDOKAN KEMİK TÜMÖRLERİNDE BENİNG-MALİGN AYRIMI YAPABİLİR Mİ ?

ENDOKAN KEMİK TÜMÖRLERİNDE

BENİNG-MALİGN AYRIMI YAPABİLİR Mİ ?<o:p></o:p>

Amaç<o:p></o:p>

İnflamasyon ve anjiyogenezde önemli rol oynayan endokan,

birçok malign tümör grubunda tümör ilerlemesini ve prognozunu değerlendirmek

için etkili bir aracıdır. Burada, endokanın malign ve benign kemik tümörlerini

ayırt etmek için bir biyobelirteç olarak kullanılıp kullanılamayacağını

araştırdık. <o:p></o:p>

Yöntem<o:p></o:p>

Patolojik olarak malign kemik tümörü olan 30 hasta, benign

kemik tümörü olan 30 hasta ve tümör öyküsü olmayan 30 kontrol hastası çalışmaya

dahil edildi. Üç grubun yaş ve cinsiyet dağılımları istatistiksel olarak

benzerdi. Biyopsi öncesinde herhangi bir tıbbi veya cerrahi müdahale geçirmemiş

hastalardan kan örnekleri alındı. Numuneler santrifüj edildi ve uygun

koşullarda saklandı. <o:p></o:p>

Pathological

Diagnosis of Patient Groups<o:p></o:p>

<table class="MsoTableGrid" border="1" cellspacing="0" cellpadding="0" align="left" style="border: none; margin-left: 4.8pt; margin-right: 4.8pt;">

<tbody><tr>

<td width="302" valign="top" style="width:226.55pt;border-top:solid windowtext 1.0pt;

border-left:none;border-bottom:solid windowtext 1.0pt;border-right:none;

mso-border-top-alt:solid windowtext .5pt;mso-border-bottom-alt:solid windowtext .5pt;

padding:0cm 5.4pt 0cm 5.4pt">

Malign Bone Tumours<o:p></o:p>

</td>

<td width="302" valign="top" style="width:226.55pt;border-top:solid windowtext 1.0pt;

border-left:none;border-bottom:solid windowtext 1.0pt;border-right:none;

mso-border-top-alt:solid windowtext .5pt;mso-border-bottom-alt:solid windowtext .5pt;

padding:0cm 5.4pt 0cm 5.4pt">

Benign Bone Tumours<o:p></o:p>

</td>

</tr>

</tbody></table>

<table class="MsoTableGrid" border="1" cellspacing="0" cellpadding="0" style="box-sizing: border-box; border-spacing: 0px; border-collapse: collapse; background-color: transparent; border: none;"><tbody style="box-sizing: border-box;"><tr style="box-sizing: border-box;"><td width="170" valign="top" style="box-sizing: border-box; padding: 0cm 5.4pt; width: 127.35pt; border-top: 1pt solid windowtext; border-left: none; border-bottom: 1pt solid windowtext; border-right: none;">Chondrosarcoma<o:p style="box-sizing: border-box;"></o:p>

</td><td width="132" valign="top" style="box-sizing: border-box; padding: 0cm 5.4pt; width: 99.2pt; border-top: 1pt solid windowtext; border-left: none; border-bottom: 1pt solid windowtext; border-right: none;">4<o:p style="box-sizing: border-box;"></o:p>

</td><td width="151" valign="top" style="box-sizing: border-box; padding: 0cm 5.4pt; width: 113.25pt; border-top: 1pt solid windowtext; border-left: none; border-bottom: 1pt solid windowtext; border-right: none;">Fibrous Dysplasia<o:p style="box-sizing: border-box;"></o:p>

</td><td width="151" valign="top" style="box-sizing: border-box; padding: 0cm 5.4pt; width: 113.3pt; border-top: 1pt solid windowtext; border-left: none; border-bottom: 1pt solid windowtext; border-right: none;">7<o:p style="box-sizing: border-box;"></o:p>

</td></tr><tr style="box-sizing: border-box; height: 36.65pt;"><td width="170" valign="top" style="box-sizing: border-box; padding: 0cm 5.4pt; width: 127.35pt; border-top: none; border-right: none; border-left: none; border-image: initial; border-bottom: 1pt solid windowtext; height: 36.65pt;">Osteosarcoma<o:p style="box-sizing: border-box;"></o:p>

</td><td width="132" valign="top" style="box-sizing: border-box; padding: 0cm 5.4pt; width: 99.2pt; border-top: none; border-right: none; border-left: none; border-image: initial; border-bottom: 1pt solid windowtext; height: 36.65pt;">4<o:p style="box-sizing: border-box;"></o:p>

</td><td width="151" valign="top" style="box-sizing: border-box; padding: 0cm 5.4pt; width: 113.25pt; border-top: none; border-right: none; border-left: none; border-image: initial; border-bottom: 1pt solid windowtext; height: 36.65pt;">Aneurysmal Bone Cyst<o:p style="box-sizing: border-box;"></o:p>

</td><td width="151" valign="top" style="box-sizing: border-box; padding: 0cm 5.4pt; width: 113.3pt; border-top: none; border-right: none; border-left: none; border-image: initial; border-bottom: 1pt solid windowtext; height: 36.65pt;">6<o:p style="box-sizing: border-box;"></o:p>

</td></tr><tr style="box-sizing: border-box;"><td width="170" valign="top" style="box-sizing: border-box; padding: 0cm 5.4pt; width: 127.35pt; border-top: none; border-right: none; border-left: none; border-image: initial; border-bottom: 1pt solid windowtext;">Ewing Sarcoma<o:p style="box-sizing: border-box;"></o:p>

</td><td width="132" valign="top" style="box-sizing: border-box; padding: 0cm 5.4pt; width: 99.2pt; border-top: none; border-right: none; border-left: none; border-image: initial; border-bottom: 1pt solid windowtext;">3<o:p style="box-sizing: border-box;"></o:p>

</td><td width="151" valign="top" style="box-sizing: border-box; padding: 0cm 5.4pt; width: 113.25pt; border-top: none; border-right: none; border-left: none; border-image: initial; border-bottom: 1pt solid windowtext;">Simple Bone Cyst<o:p style="box-sizing: border-box;"></o:p>

</td><td width="151" valign="top" style="box-sizing: border-box; padding: 0cm 5.4pt; width: 113.3pt; border-top: none; border-right: none; border-left: none; border-image: initial; border-bottom: 1pt solid windowtext;">5<o:p style="box-sizing: border-box;"></o:p>

</td></tr><tr style="box-sizing: border-box;"><td width="170" valign="top" style="box-sizing: border-box; padding: 0cm 5.4pt; width: 127.35pt; border-top: none; border-right: none; border-left: none; border-image: initial; border-bottom: 1pt solid windowtext;">Lung Adenocarcinoma Metastasis<o:p style="box-sizing: border-box;"></o:p>

</td><td width="132" valign="top" style="box-sizing: border-box; padding: 0cm 5.4pt; width: 99.2pt; border-top: none; border-right: none; border-left: none; border-image: initial; border-bottom: 1pt solid windowtext;">6<o:p style="box-sizing: border-box;"></o:p>

</td><td width="151" valign="top" style="box-sizing: border-box; padding: 0cm 5.4pt; width: 113.25pt; border-top: none; border-right: none; border-left: none; border-image: initial; border-bottom: 1pt solid windowtext;">Osteochondroma<o:p style="box-sizing: border-box;"></o:p>

</td><td width="151" valign="top" style="box-sizing: border-box; padding: 0cm 5.4pt; width: 113.3pt; border-top: none; border-right: none; border-left: none; border-image: initial; border-bottom: 1pt solid windowtext;">4<o:p style="box-sizing: border-box;"></o:p>

</td></tr><tr style="box-sizing: border-box;"><td width="170" valign="top" style="box-sizing: border-box; padding: 0cm 5.4pt; width: 127.35pt; border-top: none; border-right: none; border-left: none; border-image: initial; border-bottom: 1pt solid windowtext;">Renal Cell Carcinoma Metastasis<o:p style="box-sizing: border-box;"></o:p>

</td><td width="132" valign="top" style="box-sizing: border-box; padding: 0cm 5.4pt; width: 99.2pt; border-top: none; border-right: none; border-left: none; border-image: initial; border-bottom: 1pt solid windowtext;">4<o:p style="box-sizing: border-box;"></o:p>

</td><td width="151" valign="top" style="box-sizing: border-box; padding: 0cm 5.4pt; width: 113.25pt; border-top: none; border-right: none; border-left: none; border-image: initial; border-bottom: 1pt solid windowtext;">Enchondroma<o:p style="box-sizing: border-box;"></o:p>

</td><td width="151" valign="top" style="box-sizing: border-box; padding: 0cm 5.4pt; width: 113.3pt; border-top: none; border-right: none; border-left: none; border-image: initial; border-bottom: 1pt solid windowtext;">6<o:p style="box-sizing: border-box;"></o:p>

</td></tr><tr style="box-sizing: border-box;"><td width="170" valign="top" style="box-sizing: border-box; padding: 0cm 5.4pt; width: 127.35pt; border-top: none; border-right: none; border-left: none; border-image: initial; border-bottom: 1pt solid windowtext;">Prostate Carcinoma Metastasis<o:p style="box-sizing: border-box;"></o:p>

</td><td width="132" valign="top" style="box-sizing: border-box; padding: 0cm 5.4pt; width: 99.2pt; border-top: none; border-right: none; border-left: none; border-image: initial; border-bottom: 1pt solid windowtext;">4<o:p style="box-sizing: border-box;"></o:p>

</td><td width="151" valign="top" style="box-sizing: border-box; padding: 0cm 5.4pt; width: 113.25pt; border-top: none; border-right: none; border-left: none; border-image: initial; border-bottom: 1pt solid windowtext;">Others<o:p style="box-sizing: border-box;"></o:p>

</td><td width="151" valign="top" style="box-sizing: border-box; padding: 0cm 5.4pt; width: 113.3pt; border-top: none; border-right: none; border-left: none; border-image: initial; border-bottom: 1pt solid windowtext;">2<o:p style="box-sizing: border-box;"></o:p>

</td></tr><tr style="box-sizing: border-box;"><td width="170" valign="top" style="box-sizing: border-box; padding: 0cm 5.4pt; width: 127.35pt; border-top: none; border-right: none; border-left: none; border-image: initial; border-bottom: 1pt solid windowtext;">İnvasive Breast Sarcoma Metastasis<o:p style="box-sizing: border-box;"></o:p>

</td><td width="132" valign="top" style="box-sizing: border-box; padding: 0cm 5.4pt; width: 99.2pt; border-top: none; border-right: none; border-left: none; border-image: initial; border-bottom: 1pt solid windowtext;">2<o:p style="box-sizing: border-box;"></o:p>

</td><td width="151" valign="top" style="box-sizing: border-box; padding: 0cm 5.4pt; width: 113.25pt; border-top: none; border-right: none; border-left: none; border-image: initial; border-bottom: 1pt solid windowtext;">

</td><td width="151" valign="top" style="box-sizing: border-box; padding: 0cm 5.4pt; width: 113.3pt; border-top: none; border-right: none; border-left: none; border-image: initial; border-bottom: 1pt solid windowtext;">

</td></tr><tr style="box-sizing: border-box;"><td width="170" valign="top" style="box-sizing: border-box; padding: 0cm 5.4pt; width: 127.35pt; border-top: none; border-right: none; border-left: none; border-image: initial; border-bottom: 1pt solid windowtext;">Other<o:p style="box-sizing: border-box;"></o:p>

</td><td width="132" valign="top" style="box-sizing: border-box; padding: 0cm 5.4pt; width: 99.2pt; border-top: none; border-right: none; border-left: none; border-image: initial; border-bottom: 1pt solid windowtext;">3<o:p style="box-sizing: border-box;"></o:p>

</td><td width="151" valign="top" style="box-sizing: border-box; padding: 0cm 5.4pt; width: 113.25pt; border-top: none; border-right: none; border-left: none; border-image: initial; border-bottom: 1pt solid windowtext;">

</td><td width="151" valign="top" style="box-sizing: border-box; padding: 0cm 5.4pt; width: 113.3pt; border-top: none; border-right: none; border-left: none; border-image: initial; border-bottom: 1pt solid windowtext;">

</td></tr><tr style="box-sizing: border-box;"><td width="170" valign="top" style="box-sizing: border-box; padding: 0cm 5.4pt; width: 127.35pt; border-top: none; border-right: none; border-left: none; border-image: initial; border-bottom: 1pt solid windowtext;">

</td><td width="132" valign="top" style="box-sizing: border-box; padding: 0cm 5.4pt; width: 99.2pt; border-top: none; border-right: none; border-left: none; border-image: initial; border-bottom: 1pt solid windowtext;">30<o:p style="box-sizing: border-box;"></o:p>

</td><td width="151" valign="top" style="box-sizing: border-box; padding: 0cm 5.4pt; width: 113.25pt; border-top: none; border-right: none; border-left: none; border-image: initial; border-bottom: 1pt solid windowtext;">

</td><td width="151" valign="top" style="box-sizing: border-box; padding: 0cm 5.4pt; width: 113.3pt; border-top: none; border-right: none; border-left: none; border-image: initial; border-bottom: 1pt solid windowtext;">30<o:p style="box-sizing: border-box;"></o:p>

</td></tr></tbody></table><table class="MsoTableGrid" border="1" cellspacing="0" cellpadding="0" style="border: none;">

</table>Bulgular<o:p></o:p>

Malign ve benign kemik tümör grupları arasında endokan

seviyelerinde anlamlı bir fark vardı. Benzer şekilde, kemik tümörü olmayan grup

ile benign veya malign kemik tümörü olan gruplar arasında anlamlı bir fark

tespit edildi. Serum endokan düzeyleri ile kemik tümörlerinin malignite

potansiyeli arasında istatistiksel olarak anlamlı bir korelasyon gözlendi<o:p></o:p>

<o:p> </o:p>

<o:p> </o:p>

Table 2<o:p></o:p>

Analysis

of Laboratory Findings <o:p></o:p>

<table class="MsoTableGrid" border="1" cellspacing="0" cellpadding="0" width="642" style="width: 481.7pt; border: none;">

<tbody><tr>

<td width="121" valign="top" style="width:90.6pt;border-top:solid windowtext 1.0pt;

border-left:none;border-bottom:solid windowtext 1.0pt;border-right:none;

mso-border-top-alt:solid windowtext .5pt;mso-border-bottom-alt:solid windowtext .5pt;

padding:0cm 5.4pt 0cm 5.4pt">

</td>

<td width="121" valign="top" style="width:90.6pt;border-top:solid windowtext 1.0pt;

border-left:none;border-bottom:solid windowtext 1.0pt;border-right:none;

mso-border-top-alt:solid windowtext .5pt;mso-border-bottom-alt:solid windowtext .5pt;

padding:0cm 5.4pt 0cm 5.4pt">

Control Group (n = 30) <o:p></o:p>

Mean ± SD<o:p></o:p>

</td>

<td width="121" valign="top" style="width:90.6pt;border-top:solid windowtext 1.0pt;

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mso-border-top-alt:solid windowtext .5pt;mso-border-bottom-alt:solid windowtext .5pt;

padding:0cm 5.4pt 0cm 5.4pt">

Benign Patients (n = 30) <o:p></o:p>

Mean ± SD<o:p></o:p>

</td>

<td width="121" valign="top" style="width:90.65pt;border-top:solid windowtext 1.0pt;

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Malign Patients (n = 30) <o:p></o:p>

Mean ± SD<o:p></o:p>

</td>

<td width="159" valign="top" style="width:119.25pt;border-top:solid windowtext 1.0pt;

border-left:none;border-bottom:solid windowtext 1.0pt;border-right:none;

mso-border-top-alt:solid windowtext .5pt;mso-border-bottom-alt:solid windowtext .5pt;

padding:0cm 5.4pt 0cm 5.4pt">

p<o:p></o:p>

</td>

</tr>

<tr style="mso-yfti-irow:1;height:57.6pt">

<td width="121" valign="top" style="width:90.6pt;border:none;border-bottom:solid windowtext 1.0pt;

mso-border-top-alt:solid windowtext .5pt;mso-border-top-alt:solid windowtext .5pt;

mso-border-bottom-alt:solid windowtext .5pt;padding:0cm 5.4pt 0cm 5.4pt;

height:57.6pt">

Endocan Level (ng/mL)<o:p></o:p>

</td>

<td width="121" valign="top" style="width:90.6pt;border:none;border-bottom:solid windowtext 1.0pt;

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height:57.6pt">

103.80 ± 38.66<o:p></o:p>

</td>

<td width="121" valign="top" style="width:90.6pt;border:none;border-bottom:solid windowtext 1.0pt;

mso-border-top-alt:solid windowtext .5pt;mso-border-top-alt:solid windowtext .5pt;

mso-border-bottom-alt:solid windowtext .5pt;padding:0cm 5.4pt 0cm 5.4pt;

height:57.6pt">

142.63 ± 28.04<o:p></o:p>

</td>

<td width="121" valign="top" style="width:90.65pt;border:none;border-bottom:solid windowtext 1.0pt;

mso-border-top-alt:solid windowtext .5pt;mso-border-top-alt:solid windowtext .5pt;

mso-border-bottom-alt:solid windowtext .5pt;padding:0cm 5.4pt 0cm 5.4pt;

height:57.6pt">

350.62 ± 46.46<o:p></o:p>

</td>

<td width="159" valign="top" style="width:119.25pt;border:none;border-bottom:

solid windowtext 1.0pt;mso-border-top-alt:solid windowtext .5pt;mso-border-top-alt:

solid windowtext .5pt;mso-border-bottom-alt:solid windowtext .5pt;padding:

0cm 5.4pt 0cm 5.4pt;height:57.6pt">

.001a<o:p></o:p>

.001b<o:p></o:p>

.001c<o:p></o:p>

</td>

</tr>

<tr style="mso-yfti-irow:2;height:38.5pt">

<td width="121" valign="top" style="width:90.6pt;border:none;border-bottom:solid windowtext 1.0pt;

mso-border-top-alt:solid windowtext .5pt;mso-border-top-alt:solid windowtext .5pt;

mso-border-bottom-alt:solid windowtext .5pt;padding:0cm 5.4pt 0cm 5.4pt;

height:38.5pt">

Hb<o:p></o:p>

</td>

<td width="121" valign="top" style="width:90.6pt;border:none;border-bottom:solid windowtext 1.0pt;

mso-border-top-alt:solid windowtext .5pt;mso-border-top-alt:solid windowtext .5pt;

mso-border-bottom-alt:solid windowtext .5pt;padding:0cm 5.4pt 0cm 5.4pt;

height:38.5pt">

12.49 ± 2.24<o:p></o:p>

</td>

<td width="121" valign="top" style="width:90.6pt;border:none;border-bottom:solid windowtext 1.0pt;

mso-border-top-alt:solid windowtext .5pt;mso-border-top-alt:solid windowtext .5pt;

mso-border-bottom-alt:solid windowtext .5pt;padding:0cm 5.4pt 0cm 5.4pt;

height:38.5pt">

13.09 ± 2.33<o:p></o:p>

</td>

<td width="121" valign="top" style="width:90.65pt;border:none;border-bottom:solid windowtext 1.0pt;

mso-border-top-alt:solid windowtext .5pt;mso-border-top-alt:solid windowtext .5pt;

mso-border-bottom-alt:solid windowtext .5pt;padding:0cm 5.4pt 0cm 5.4pt;

height:38.5pt">

12.65 ± 1.87<o:p></o:p>

</td>

<td width="159" valign="top" style="width:119.25pt;border:none;border-bottom:

solid windowtext 1.0pt;mso-border-top-alt:solid windowtext .5pt;mso-border-top-alt:

solid windowtext .5pt;mso-border-bottom-alt:solid windowtext .5pt;padding:

0cm 5.4pt 0cm 5.4pt;height:38.5pt">

.534a<o:p></o:p>

.957b<o:p></o:p>

.710c<o:p></o:p>

</td>

</tr>

<tr>

<td width="121" valign="top" style="width:90.6pt;border:none;border-bottom:solid windowtext 1.0pt;

mso-border-top-alt:solid windowtext .5pt;mso-border-top-alt:solid windowtext .5pt;

mso-border-bottom-alt:solid windowtext .5pt;padding:0cm 5.4pt 0cm 5.4pt">

WBC<o:p></o:p>

</td>

<td width="121" valign="top" style="width:90.6pt;border:none;border-bottom:solid windowtext 1.0pt;

mso-border-top-alt:solid windowtext .5pt;mso-border-top-alt:solid windowtext .5pt;

mso-border-bottom-alt:solid windowtext .5pt;padding:0cm 5.4pt 0cm 5.4pt">

8.73 ± 2.40<o:p></o:p>

</td>

<td width="121" valign="top" style="width:90.6pt;border:none;border-bottom:solid windowtext 1.0pt;

mso-border-top-alt:solid windowtext .5pt;mso-border-top-alt:solid windowtext .5pt;

mso-border-bottom-alt:solid windowtext .5pt;padding:0cm 5.4pt 0cm 5.4pt">

8.19 ± 2.38<o:p></o:p>

</td>

<td width="121" valign="top" style="width:90.65pt;border:none;border-bottom:solid windowtext 1.0pt;

mso-border-top-alt:solid windowtext .5pt;mso-border-top-alt:solid windowtext .5pt;

mso-border-bottom-alt:solid windowtext .5pt;padding:0cm 5.4pt 0cm 5.4pt">

8.95 ± 4.34<o:p></o:p>

</td>

<td width="159" valign="top" style="width:119.25pt;border:none;border-bottom:

solid windowtext 1.0pt;mso-border-top-alt:solid windowtext .5pt;mso-border-top-alt:

solid windowtext .5pt;mso-border-bottom-alt:solid windowtext .5pt;padding:

0cm 5.4pt 0cm 5.4pt">

.787a<o:p></o:p>

.960b<o:p></o:p>

.622c<o:p></o:p>

</td>

</tr>

<tr>

<td width="121" valign="top" style="width:90.6pt;border:none;border-bottom:solid windowtext 1.0pt;

mso-border-top-alt:solid windowtext .5pt;mso-border-top-alt:solid windowtext .5pt;

mso-border-bottom-alt:solid windowtext .5pt;padding:0cm 5.4pt 0cm 5.4pt">

Neu/Lym*<o:p></o:p>

</td>

<td width="121" valign="top" style="width:90.6pt;border:none;border-bottom:solid windowtext 1.0pt;

mso-border-top-alt:solid windowtext .5pt;mso-border-top-alt:solid windowtext .5pt;

mso-border-bottom-alt:solid windowtext .5pt;padding:0cm 5.4pt 0cm 5.4pt">

0.81–9.51<o:p></o:p>

</td>

<td width="121" valign="top" style="width:90.6pt;border:none;border-bottom:solid windowtext 1.0pt;

mso-border-top-alt:solid windowtext .5pt;mso-border-top-alt:solid windowtext .5pt;

mso-border-bottom-alt:solid windowtext .5pt;padding:0cm 5.4pt 0cm 5.4pt">

0.95–7.83<o:p></o:p>

</td>

<td width="121" valign="top" style="width:90.65pt;border:none;border-bottom:solid windowtext 1.0pt;

mso-border-top-alt:solid windowtext .5pt;mso-border-top-alt:solid windowtext .5pt;

mso-border-bottom-alt:solid windowtext .5pt;padding:0cm 5.4pt 0cm 5.4pt">

0.99–40.12<o:p></o:p>

</td>

<td width="159" valign="top" style="width:119.25pt;border:none;border-bottom:

solid windowtext 1.0pt;mso-border-top-alt:solid windowtext .5pt;mso-border-top-alt:

solid windowtext .5pt;mso-border-bottom-alt:solid windowtext .5pt;padding:

0cm 5.4pt 0cm 5.4pt">

.965a<o:p></o:p>

.544b<o:p></o:p>

.469c<o:p></o:p>

</td>

</tr>

<tr>

<td width="121" valign="top" style="width:90.6pt;border:none;border-bottom:solid windowtext 1.0pt;

mso-border-top-alt:solid windowtext .5pt;mso-border-top-alt:solid windowtext .5pt;

mso-border-bottom-alt:solid windowtext .5pt;padding:0cm 5.4pt 0cm 5.4pt">

CRP*<o:p></o:p>

</td>

<td width="121" valign="top" style="width:90.6pt;border:none;border-bottom:solid windowtext 1.0pt;

mso-border-top-alt:solid windowtext .5pt;mso-border-top-alt:solid windowtext .5pt;

mso-border-bottom-alt:solid windowtext .5pt;padding:0cm 5.4pt 0cm 5.4pt">

1–14<o:p></o:p>

</td>

<td width="121" valign="top" style="width:90.6pt;border:none;border-bottom:solid windowtext 1.0pt;

mso-border-top-alt:solid windowtext .5pt;mso-border-top-alt:solid windowtext .5pt;

mso-border-bottom-alt:solid windowtext .5pt;padding:0cm 5.4pt 0cm 5.4pt">

1–30.19<o:p></o:p>

</td>

<td width="121" valign="top" style="width:90.65pt;border:none;border-bottom:solid windowtext 1.0pt;

mso-border-top-alt:solid windowtext .5pt;mso-border-top-alt:solid windowtext .5pt;

mso-border-bottom-alt:solid windowtext .5pt;padding:0cm 5.4pt 0cm 5.4pt">

2.7–149<o:p></o:p>

</td>

<td width="159" valign="top" style="width:119.25pt;border:none;border-bottom:

solid windowtext 1.0pt;mso-border-top-alt:solid windowtext .5pt;mso-border-top-alt:

solid windowtext .5pt;mso-border-bottom-alt:solid windowtext .5pt;padding:

0cm 5.4pt 0cm 5.4pt">

.695a<o:p></o:p>

.001b<o:p></o:p>

.001c<o:p></o:p>

</td>

</tr>

<tr>

<td width="121" valign="top" style="width:90.6pt;border:none;border-bottom:solid windowtext 1.0pt;

mso-border-top-alt:solid windowtext .5pt;mso-border-top-alt:solid windowtext .5pt;

mso-border-bottom-alt:solid windowtext .5pt;padding:0cm 5.4pt 0cm 5.4pt">

ESR*<o:p></o:p>

</td>

<td width="121" valign="top" style="width:90.6pt;border:none;border-bottom:solid windowtext 1.0pt;

mso-border-top-alt:solid windowtext .5pt;mso-border-top-alt:solid windowtext .5pt;

mso-border-bottom-alt:solid windowtext .5pt;padding:0cm 5.4pt 0cm 5.4pt">

3–9<o:p></o:p>

</td>

<td width="121" valign="top" style="width:90.6pt;border:none;border-bottom:solid windowtext 1.0pt;

mso-border-top-alt:solid windowtext .5pt;mso-border-top-alt:solid windowtext .5pt;

mso-border-bottom-alt:solid windowtext .5pt;padding:0cm 5.4pt 0cm 5.4pt">

3–26<o:p></o:p>

</td>

<td width="121" valign="top" style="width:90.65pt;border:none;border-bottom:solid windowtext 1.0pt;

mso-border-top-alt:solid windowtext .5pt;mso-border-top-alt:solid windowtext .5pt;

mso-border-bottom-alt:solid windowtext .5pt;padding:0cm 5.4pt 0cm 5.4pt">

3–85<o:p></o:p>

</td>

<td width="159" valign="top" style="width:119.25pt;border:none;border-bottom:

solid windowtext 1.0pt;mso-border-top-alt:solid windowtext .5pt;mso-border-top-alt:

solid windowtext .5pt;mso-border-bottom-alt:solid windowtext .5pt;padding:

0cm 5.4pt 0cm 5.4pt">

.153a<o:p></o:p>

.001b<o:p></o:p>

.001c<o:p></o:p>

</td>

</tr>

</tbody></table>

Sonuç<o:p></o:p>

Bu sonuçlar, endokanın bir kemik tümörünün iyi huylu mu

yoksa kötü huylu mu olduğunu belirlemek için bir biyobelirteç olarak

kullanılabileceğini göstermektedir. Ek olarak, bir kemik tümörünün ciddiyeti

endokan seviyelerine göre belirlenebilir.<o:p></o:p>