Atatürk Üniversitesi Atatürk Üniversitesi
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Makale Tam Makale Uluslararası 2021

iNetModels 2.0: an interactive visualization and database of multi-omics data

Muhammad Arif, Cheng Zhang, Xiangyu Li, Cem Gungor, Bugra Cakmak, Metin Arslanturk, Abdellah Tebani, Berkay Ozcan, Oguzhan Subas, Wenyu Zhou, Brian Piening, Hasan Türkez, Linn Fagerberg, Nathan Price, Leroy Hood, Michael Snyder, Jens Nielsen, Mathias Uhlen, Adil Mardinoglu

NUCLEIC ACIDS RESEARCH Cilt 49 · 01.07.2021
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Özet

It is essential to reveal the associations between various omics data for a comprehensive understanding of the altered biological process in human wellness and disease. To date, very few studies have focused on collecting and exhibiting multi-omics associations in a single database. Here, we present iNetModels, an interactive database and visualization platform of Multi-Omics Biological Networks (MOBNs). This platform describes the associations between the clinical chemistry, anthropometric parameters, plasma proteomics, plasma metabolomics, as well as metagenomics for oral and gut microbiome obtained from the same individuals. Moreover, iNetModels includes tissue- and cancer-specific Gene Co-expression Networks (GCNs) for exploring the connections between the specific genes. This platform allows the user to interactively explore a single feature's association with other omics data and customize its particular context (e.g. male/female specific). The users can also register their data for sharing and visualization of the MOBNs and GCNs. Moreover, iNetModels allows users who do not have a bioinformatics background to facilitate human wellness and disease research. iNetModels can be accessed freely at https://inetmodels.com without any limitation.

Sürdürülebilir Kalkınma Amaçları

  • SKA 3: Sağlıklı Bireyler

Atıf için künye

Arif, M., Zhang, C., Li, X., Gungor, C., Cakmak, B., Arslanturk, M., Tebani, A., Ozcan, B., Subas, O., Zhou, W., Piening, B., Türkez, H., Fagerberg, L., Price, N., Hood, L., Snyder, M., Nielsen, J., Uhlen, M., & Mardinoglu, A. (2021). iNetModels 2.0: an interactive visualization and database of multi-omics data. NUCLEIC ACIDS RESEARCH, 49. https://doi.org/10.1093/nar/gkab254

BibTeX 
@article{arif2021-245028,
  author = {Arif, Muhammad and Zhang, Cheng and Li, Xiangyu and Gungor, Cem and Cakmak, Bugra and Arslanturk, Metin and Tebani, Abdellah and Ozcan, Berkay and Subas, Oguzhan and Zhou, Wenyu and Piening, Brian and Türkez, Hasan and Fagerberg, Linn and Price, Nathan and Hood, Leroy and Snyder, Michael and Nielsen, Jens and Uhlen, Mathias and Mardinoglu, Adil},
  title = {iNetModels 2.0: an interactive visualization and database of multi-omics data},
  journal = {NUCLEIC ACIDS RESEARCH},
  year = {2021},
  volume = {49},
  issn = {0305-1048},
  doi = {10.1093/nar/gkab254},
  url = {https://akademik.atauni.edu.tr/yayinlar/245028-inetmodels-20-an-interactive-visualization-and-database-of-multi-omics-data}
}