A systems biology approach for studying neurodegenerative diseases
Özet
Neurodegenerative diseases (NDDs), such as Alzheimer's (AD) and Parkinson's (PD), are among the leading causes of lost years of healthy life and exert a great strain on public healthcare systems. Despite being first described more than a century ago, no effective cure exists for AD or PD. Although extensively characterised at the molecular level, traditional neurodegeneration research remains marred by narrow-sense approaches surrounding amyloid beta (A beta), tau, and alpha-synuclein (alpha-syn). A systems biology approach enables the integration of multi-omics data and informs discovery of biomarkers, drug targets, and treatment strategies. Here, we present a comprehensive timeline of high-throughput data collection, and associated biotechnological advancements and computational analysis related to AD and PD. We hereby propose that a philosophical change in the definitions of AD and PD is now needed.
Atıf için künye
Lam, S., Bayraktar, A., Zhang, C., Türkez, H., Nielsen, J., Boren, J., Shoaie, S., Uhlen, M., & Mardinoglu, A. (2020). A systems biology approach for studying neurodegenerative diseases. DRUG DISCOVERY TODAY, 25(7), 1146–1159. https://doi.org/10.1016/j.drudis.2020.05.010
BibTeX
@article{lam2020-244976,
author = {Lam, Simon and Bayraktar, Abdulahad and Zhang, Cheng and Türkez, Hasan and Nielsen, Jens and Boren, Jan and Shoaie, Saeed and Uhlen, Mathias and Mardinoglu, Adil},
title = {A systems biology approach for studying neurodegenerative diseases},
journal = {DRUG DISCOVERY TODAY},
year = {2020},
volume = {25},
number = {7},
pages = {1146--1159},
issn = {1359-6446},
doi = {10.1016/j.drudis.2020.05.010},
url = {https://akademik.atauni.edu.tr/yayinlar/244976-a-systems-biology-approach-for-studying-neurodegenerative-diseases}
}