Makale
Tam Makale
Uluslararası
2019
The in vitro cytotoxicity, genotoxicity and oxidative damage potential of dapagliflozin, on cultured human blood cells
TURKISH JOURNAL OF BIOCHEMISTRY-TURK BIYOKIMYA DERGISI
Cilt 44 · Sayı 5 · ss. 692–698 · 01.10.2019
Özet
Objectives: Dapagliflozin (DAPA), is a potent SGLT-2 inhibitor for the treatment of patients with type 2 diabetes. DAPA has a good clinical and biological tolerance profile. However little information is available on its potential effects on cultured human blood cells. The evaluation of the in vitro cytotoxicity, genotoxicity potential and antioxidant/oxidant activity of DAPA in primary human whole blood cell cultures was aimed in this study.
Anahtar kelimeler
stress
RISK
DOUBLE-BLIND
INHIBITORS
GENOTOXICITY
LDH
MTT
Dapagliflozin
WEIGHT
GLYCEMIC CONTROL
Oxidant status
TYPE-2 DIABETIC-PATIENTS
GLUCOSE COTRANSPORTER 2
CHRONIC SAFETY
Sürdürülebilir Kalkınma Amaçları
-
SKA 3: Sağlıklı Bireyler
Atıf için künye
Türkez, H., TOZLU, Ö. Ö., & TÜRKEZ, H. (2019). The in vitro cytotoxicity, genotoxicity and oxidative damage potential of dapagliflozin, on cultured human blood cells. TURKISH JOURNAL OF BIOCHEMISTRY-TURK BIYOKIMYA DERGISI, 44(5), 692–698. https://doi.org/10.1515/tjb-2019-0111
BibTeX
@article{turkez2019-244952,
author = {Türkez, Hasan and TOZLU, ÖZLEM ÖZDEMİR and TÜRKEZ, HASAN},
title = {The in vitro cytotoxicity, genotoxicity and oxidative damage potential of dapagliflozin, on cultured human blood cells},
journal = {TURKISH JOURNAL OF BIOCHEMISTRY-TURK BIYOKIMYA DERGISI},
year = {2019},
volume = {44},
number = {5},
pages = {692--698},
issn = {0250-4685},
doi = {10.1515/tjb-2019-0111},
url = {https://akademik.atauni.edu.tr/yayinlar/244952-the-in-vitro-cytotoxicity-genotoxicity-and-oxidative-damage-potential-of}
}