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Makale Tam Makale Uluslararası 2025

Genomic Surveillance and Molecular Characterization of SARS-CoV-2 Variants During the Peak of the Pandemic in Türkiye

Faruk Berat Akçeşme, Tuğba Kul Köprülü, Burçin Erkal Çam, Şeyma İş, Birsen Cevher Keskin, Betül Akçeşme, Kürşad Nuri Baydili, Bahar Gezer, Jülide Balkan, Bihter Uçar, Osman Gürsoy, Mehmet Taha Yıldız, Halil Kurt, Nevzat Ünal, Celalettin Korkmaz, Özlem Bayraktar Saral, Barış Demirkol, Yasemin Çağ, Hilal Abakay, Şükran Köse, Hasan Türkez, Mustafa Altındiş, Yasemin Derya Gülseren, Nuray Aslan, Abdulkadir Özel, Muhammet Atıf Karagöl, Neslihan Mutluay, Şaban Tekin

BIOCHEMICAL GENETICS Cilt 63 · Sayı 5 · ss. 4770–4789 · 01.10.2025
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Özet

SARS-CoV-2 is a highly transmissible coronavirus and has caused a pandemic of acute respiratory disease. Genomic characterization of SARS-CoV-2 is important for monitoring and assessing its evolution. A total of 1.346 nasopharyngeal swab samples were collected but only 879 SARS-CoV-2 high-quality genomes were isolated, subjected to Next Generation Sequencing and analyzed both statistically and regarding mutations comprehensively. The distribution of clades and lineages in different cities of Türkiye and the association of SARS-CoV-2 variants with age groups and clinical characteristics of COVID-19 were also examined. Furthermore, the frequency of the clades and lineages was observed in 10 months. Finally, non-synonymous mutations not defined in specific SARS-CoV-2 variants (during that period) were identified by performing mutation analysis. B.1.1.7 (Alpha) and B.1.617.2 (Delta) SARS-CoV-2 variants which have also been identified in our study from March to December 2021. We observed a significant association of SARS-CoV-2 variants with age groups and cities. Also, E:T9I, S:A27S, S:A67V, S:D796Y, S:K417N, S:N440K, S:R158X, S:S477N (below 1%-frequency) were determined as specific mutations belonging and shared with the Omicron variant that appeared later. Our study has highlighted the importance of constant monitoring of the genetic diversity of SARS-CoV-2 to provide better prevention strategies and it contributes to the understanding of SARS-CoV-2 from the past to the present.

Anahtar kelimeler

MUTATIONS COVID-19 SARS-CoV-2 VARIANTS Türkiye Viral genome analysis

Atıf için künye

Akçeşme, F. B., Köprülü, T. K., Çam, B. E., İş, Ş., Keskin, B. C., Akçeşme, B., Baydili, K. N., Gezer, B., Balkan, J., Uçar, B., Gürsoy, O., Yıldız, M. T., Kurt, H., Ünal, N., Korkmaz, C., Saral, Ö. B., Demirkol, B., Çağ, Y., Abakay, H., … Tekin, Ş. (2025). Genomic Surveillance and Molecular Characterization of SARS-CoV-2 Variants During the Peak of the Pandemic in Türkiye. BIOCHEMICAL GENETICS, 63(5), 4770–4789. https://doi.org/10.1007/s10528-024-10962-8

BibTeX 
@article{akcesme2025-244944,
  author = {Akçeşme, Faruk Berat and Köprülü, Tuğba Kul and Çam, Burçin Erkal and İş, Şeyma and Keskin, Birsen Cevher and Akçeşme, Betül and Baydili, Kürşad Nuri and Gezer, Bahar and Balkan, Jülide and Uçar, Bihter and Gürsoy, Osman and Yıldız, Mehmet Taha and Kurt, Halil and Ünal, Nevzat and Korkmaz, Celalettin and Saral, Özlem Bayraktar and Demirkol, Barış and Çağ, Yasemin and Abakay, Hilal and Köse, Şükran and Türkez, Hasan and Altındiş, Mustafa and Gülseren, Yasemin Derya and Aslan, Nuray and Özel, Abdulkadir and Karagöl, Muhammet Atıf and Mutluay, Neslihan and Tekin, Şaban},
  title = {Genomic Surveillance and Molecular Characterization of SARS-CoV-2 Variants During the Peak of the Pandemic in Türkiye},
  journal = {BIOCHEMICAL GENETICS},
  year = {2025},
  volume = {63},
  number = {5},
  pages = {4770--4789},
  issn = {0006-2928},
  doi = {10.1007/s10528-024-10962-8},
  url = {https://akademik.atauni.edu.tr/yayinlar/244944-genomic-surveillance-and-molecular-characterization-of-sars-cov-2-variants}
}