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Makale Tam Makale Uluslararası 2025

Integrative proteo-transcriptomic characterization of advanced fibrosis in chronic liver disease across etiologies

Hong Yang, Dila Atak, Meng Yuan, Mengzhen Li, Ozlem Altay, Elif Demirtas, Ibrahim Batuhan Peltek, Burge Ulukan, Buket Yigit, Tarik Sipahioglu, María Bueno Álvez, Lingqi Meng, Bayram Yüksel, Hasan Türkez, Hale Kirimlioglu, Burcu Saka, Cihan Yurdaydin, Murat Akyildiz, Murat Dayangac, Mathias Uhlen, Jan Boren, Cheng Zhang, Adil Mardinoglu, Mujdat Zeybel

Cell Reports Medicine Cilt 6 · Sayı 2 · 18.02.2025
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Özet

Chronic hepatic injury and inflammation from various causes can lead to fibrosis and cirrhosis, potentially predisposing to hepatocellular carcinoma. The molecular mechanisms underlying fibrosis and its progression remain incompletely understood. Using a proteo-transcriptomics approach, we analyze liver and plasma samples from 330 individuals, including 40 healthy individuals and 290 patients with histologically characterized fibrosis due to chronic viral infection, alcohol consumption, or metabolic dysfunction-associated steatotic liver disease. Our findings reveal dysregulated pathways related to extracellular matrix, immune response, inflammation, and metabolism in advanced fibrosis. We also identify 132 circulating proteins associated with advanced fibrosis, with neurofascin and growth differentiation factor 15 demonstrating superior predictive performance for advanced fibrosis(area under the receiver operating characteristic curve [AUROC] 0.89 [95% confidence interval (CI) 0.81–0.97]) compared to the fibrosis-4 model (AUROC 0.85 [95% CI 0.78–0.93]). These findings provide insights into fibrosis pathogenesis and highlight the potential for more accurate non-invasive diagnosis.

Anahtar kelimeler

Non-Invasive chronic liver disease Multi-omics Systems biology liver fibrosis

Atıf için künye

Yang, H., Atak, D., Yuan, M., Li, M., Altay, O., Demirtas, E., Peltek, I. B., Ulukan, B., Yigit, B., Sipahioglu, T., Álvez, M. B., Meng, L., Yüksel, B., Türkez, H., Kirimlioglu, H., Saka, B., Yurdaydin, C., Akyildiz, M., Dayangac, M., … Zeybel, M. (2025). Integrative proteo-transcriptomic characterization of advanced fibrosis in chronic liver disease across etiologies. Cell Reports Medicine, 6(2). https://doi.org/10.1016/j.xcrm.2025.101935

BibTeX 
@article{yang2025-244919,
  author = {Yang, Hong and Atak, Dila and Yuan, Meng and Li, Mengzhen and Altay, Ozlem and Demirtas, Elif and Peltek, Ibrahim Batuhan and Ulukan, Burge and Yigit, Buket and Sipahioglu, Tarik and Álvez, María Bueno and Meng, Lingqi and Yüksel, Bayram and Türkez, Hasan and Kirimlioglu, Hale and Saka, Burcu and Yurdaydin, Cihan and Akyildiz, Murat and Dayangac, Murat and Uhlen, Mathias and Boren, Jan and Zhang, Cheng and Mardinoglu, Adil and Zeybel, Mujdat},
  title = {Integrative proteo-transcriptomic characterization of advanced fibrosis in chronic liver disease across etiologies},
  journal = {Cell Reports Medicine},
  year = {2025},
  volume = {6},
  number = {2},
  issn = {2666-3791},
  doi = {10.1016/j.xcrm.2025.101935},
  url = {https://akademik.atauni.edu.tr/yayinlar/244919-integrative-proteo-transcriptomic-characterization-of-advanced-fibrosis-in}
}