(R)-α-Lipoyl-Gly-l-Pro-l-Glu dimethyl ester as dual acting agent for the treatment of Alzheimer's disease.

Marinelli, L; Fornasari, E; Di, Stefano; Türkez, Hasan; Arslan, ME; Eusepi, P; Ciulla, M; Cacciatore, I

doi:10.1016/j.npep.2017.09.001

Makale Tam Makale Uluslararası 2017

(R)-α-Lipoyl-Gly-l-Pro-l-Glu dimethyl ester as dual acting agent for the treatment of Alzheimer's disease.

L Marinelli, E Fornasari, Stefano Di, Hasan Türkez, ME Arslan, P Eusepi, M Ciulla, I Cacciatore

Neuropeptides Cilt 66 · ss. 52–58 · 01.12.2017

DOI ile aç

Özet

In this study, effects of LA-GPE dimethyl ester) and GPE (Gly-L-Pro-L-Glu) on the cytotoxic action of A beta(1-42) were tested with differentiated human neuroblastoma SH-SY5Y cells as cellular Alzheimer model via measurements of mitochondria) viability (MTT assay) and lactate dehydrogenase release (LDH assay). Effects of LA-GPE and GPE on acetylcholinesterase (AChE) activity, total antioxidant capacity (TAC) and total oxidative status (TOS) levels, and neural cell apoptosis and necrosis were also determined. In addition, biological safety of these novel formulations was evaluated in human blood cells using different cytotoxicity and genotoxicity assays. Our results indicated that both compounds could block A beta(1-42) induced cell death. LA-GPE reduced A beta-induced AChE activity and oxidative stress, suggesting it as a multifunctional compound potentially valuable for the treatment of Alzheimer's disease (AD).

Anahtar kelimeler

IN-VITRO CELLS Alzheimer's disease DERIVATIVES AMYLOID-BETA ANALOGS HYPOTHESIS PEPTIDES Lipoic acid Neurodegenerative diseases Gly-pro-Glu Tripeptides GPE EPTASTIGMINE

Sürdürülebilir Kalkınma Amaçları

SKA 3: Sağlıklı Bireyler

Atıf için künye

Marinelli, L., Fornasari, E., Di, S., Türkez, H., Arslan, M., Eusepi, P., Ciulla, M., & Cacciatore, I. (2017). (R)-α-Lipoyl-Gly-l-Pro-l-Glu dimethyl ester as dual acting agent for the treatment of Alzheimer's disease. Neuropeptides, 66, 52–58. https://doi.org/10.1016/j.npep.2017.09.001

BibTeX

@article{marinelli2017-244901,
  author = {Marinelli, L and Fornasari, E and Di, Stefano and Türkez, Hasan and Arslan, ME and Eusepi, P and Ciulla, M and Cacciatore, I},
  title = {(R)-α-Lipoyl-Gly-l-Pro-l-Glu dimethyl ester as dual acting agent for the treatment of Alzheimer's disease.},
  journal = {Neuropeptides},
  year = {2017},
  volume = {66},
  pages = {52--58},
  issn = {0143-4179},
  doi = {10.1016/j.npep.2017.09.001},
  url = {https://akademik.atauni.edu.tr/yayinlar/244901-r-a-lipoyl-gly-l-pro-l-glu-dimethyl-ester-as-dual-acting-agent-for-the-treatment}
}