Machine learning based multi-omics analysis reveals key molecular determinants of Parkinson's disease severity
Özet
While single-omics analyses of Parkinson's Disease (PD) have demonstrated their ability in revealing the underlying molecular mechanisms, they often fail to provide a comprehensive view of the complete disease mechanisms. In this study, we leveraged multi-omics data from 64 heterogeneous, well-phenotyped PD patients, generated plasma metabolomics data and Olink proteomics data together with the gut and saliva metagenomics data, and investigated the altered molecular mechanisms and their interactions in association with the severity of motor function disorders in PD patients. Based on our multi-omics approach, we identified a panel of 58 biomarkers comprising one clinical variable, 10 proteins, and 17 metabolites from plasma, 26 gut species, and 4 saliva species for PD severity. These biomarkers exhibited superior predictive performance for assessing PD severity compared to those derived from single-omics datasets. The predictive power of our machine learning models based on these biomarkers was validated using additional multi-omics data from the same group of PD patients after a 3-month follow-up. The contribution of each omics dataset was evaluated by both supervised and unsupervised machine learning approaches, highlighting the importance of plasma metabolomics in disease stratification. Our study unveiled disease-related molecular alterations across multiple omics datasets, offering potential diagnostic and therapeutic insights for PD. Moreover, it underpinned the significance of employing multi-omics analyses when studying complex diseases like PD.
Anahtar kelimeler
Atıf için künye
Jin, H., Meng, L., Yulug, B., Altay, O., Li, X., Cankaya, S., HANOĞLU, L., Ji, B., Coskun, E., Idil, E., Nogaylar, R., Oktem, E. O., Sayman, D., Karaca, R., Ozsimsek, A., Shoaie, S., Türkez, H., Nielsen, J., Borén, J., … Mardinoglu, A. (2026). Machine learning based multi-omics analysis reveals key molecular determinants of Parkinson's disease severity. Neurobiology of Disease, 225. https://doi.org/10.1016/j.nbd.2026.107424
BibTeX
@article{jin2026-244873,
author = {Jin, Han and Meng, Lingqi and Yulug, Burak and Altay, Ozlem and Li, Xiangyu and Cankaya, Seyda and HANOĞLU, Lütfü and Ji, Boyu and Coskun, Ebru and Idil, Ezgi and Nogaylar, Rahim and Oktem, Ece Ozdemir and Sayman, Dila and Karaca, Ramazan and Ozsimsek, Ahmet and Shoaie, Saeed and Türkez, Hasan and Nielsen, Jens and Borén, Jan and Zhang, Cheng and Uhlén, Mathias and Mardinoglu, Adil},
title = {Machine learning based multi-omics analysis reveals key molecular determinants of Parkinson's disease severity},
journal = {Neurobiology of Disease},
year = {2026},
volume = {225},
issn = {0969-9961},
doi = {10.1016/j.nbd.2026.107424},
url = {https://akademik.atauni.edu.tr/yayinlar/244873-machine-learning-based-multi-omics-analysis-reveals-key-molecular-determinants}
}