Fixed-Dose Antiplatelet Dual Combination in Patients with Coronary Artery Disease in Turkish Population: DAPT-TR
Özet
Background: Dual antiplatelet therapy (DAPT) is the treatment of choice for patients with acute and chronic coronary syndromes as it reduces mortality and prevents recurrent thrombotic complications. The assessment of both ischaemic burden and bleeding risk is crucial in deciding which DAPT to choose and how long it should be continued. Objectives: The aim of our study was to perform prospective clinical follow-up of patients receiving fixed-dose combination therapy (ASA 75 mg + clopidogrel 75 mg). Our study is a multicentric, cross-sectional, observational, cohort study. Methods: A total of 1500 patients who were started on fixed-dose combination DAPT for acute or chronic coronary syndrome were included in the study. Primary endpoints were hospitalization for any reason, hospitalization for cardiovascular cause, acute myocardial infarction, stent thrombosis, target vessel revascularization and bleeding; the secondary endpoints were death for any reason or cardiovascular cause and stroke. The significance level adopted in the statistical analysis was 5%. Results: Median age was 63 years; 78.5% of the patients were receiving DAPT treatment for acute coronary syndrome. The rates of hospitalization for cardiovascular reasons, acute myocardial infartion, stent thrombosis and target-vessel revascularization were 7.9%, 2.3%, 1.3% and 4.2%, respectively. While the rate of BARC type 1 bleeding was 3.3%, the rate of BARC type 5, 3, or 2 bleeding was 0.6%. The secondary endpoints which were death from any cause, cardiovascular death and stroke were 0.5%, 0.3% and 0.3%, respectively. Conclusion: Our study shows that fixed-dose combination therapy is effective and safe in appropriately selected patients with acute or chronic coronary syndromes.
Anahtar kelimeler
Atıf için künye
Oz, A., Toprak, K., Aydin, E., Sarac, İ., Dogdus, M., Opan, S., Yenercag, M., Tascanov, M. B., Kumet, O., Karaagac, M., Ozmen, M., Murat, B., Kertmen, O., Bekler, O., Inci, S., Huyut, M. A., Ozderya, A., Er, F., Duran, M., … Zoghi, M. (2024). Fixed-Dose Antiplatelet Dual Combination in Patients with Coronary Artery Disease in Turkish Population: DAPT-TR. Arquivos Brasileiros de Cardiologia, 121(11). https://doi.org/10.36660/abc.20240202i
BibTeX
@article{oz2024-244823,
author = {Oz, Ahmet and Toprak, Kenan and Aydin, Ertan and Sarac, İbrahim and Dogdus, Mustafa and Opan, Selcuk and Yenercag, Mustafa and Tascanov, Mustafa Begenc and Kumet, Omer and Karaagac, Mirac and Ozmen, Murat and Murat, Bektas and Kertmen, Omer and Bekler, Ozkan and Inci, Sinan and Huyut, Mustafa Ahmet and Ozderya, Ahmet and Er, Fahri and Duran, Mustafa and Ardahanli, Isa and Bas, Mehmet Memduh and Guzel, Tuncay and Ceyhun, Gökhan and Ozdemir, Ibrahim Halil and Ozen, Mehmet Burak and Gunduz, Ramazan and Erdogan, Aslan and Cetin, Ilyas and Baris, Veysel Ozgur and Yayla, Cagri and Karaduman, Medeni and Askin, Luetfue and Bekar, Luetfue and Tanriverdi, Okan and Ozkan, Eyup and Yesil, Emrah and Caliskan, Serhat and Kuzu, Zuelfiye and Uguz, Berat and Boyuk, Ferit and Kunak, Aysegul Ulgen and Murat, Selda and Asil, Serkan and Kayhan, Ozkan and Erdogan, Emrah and Duz, Ramazan and Katkat, Fahrettin and Ekin, Tuba and Ibisoglu, Ersin and Ates, Bilge Nazar and Ayca, Burak and Ergene, Asim Oktay and Zoghi, Mehdi},
title = {Fixed-Dose Antiplatelet Dual Combination in Patients with Coronary Artery Disease in Turkish Population: DAPT-TR},
journal = {Arquivos Brasileiros de Cardiologia},
year = {2024},
volume = {121},
number = {11},
issn = {0066-782X},
doi = {10.36660/abc.20240202i},
url = {https://akademik.atauni.edu.tr/yayinlar/244823-fixed-dose-antiplatelet-dual-combination-in-patients-with-coronary-artery}
}