Fixed-Dose Antiplatelet Dual Combination in Patients with Coronary Artery Disease in Turkish Population: DAPT-TR Terapia Antiplaquetária Dupla Combinada em Pacientes com Doença Arterial Coronariana em uma População na Turquia: DAPT-TR
Özet
Background: Dual antiplatelet therapy (DAPT) is the treatment of choice for patients with acute and chronic coronary syndromes as it reduces mortality and prevents recurrent thrombotic complications. The assessment of both ischaemic burden and bleeding risk is crucial in deciding which DAPT to choose and how long it should be continued. Objectives: The aim of our study was to perform prospective clinical follow-up of patients receiving fixed-dose combination therapy (ASA 75 mg + clopidogrel 75 mg). Our study is a multicentric, cross-sectional, observational, cohort study. Methods: A total of 1500 patients who were started on fixed-dose combination DAPT for acute or chronic coronary syndrome were included in the study. Primary endpoints were hospitalization for any reason, hospitalization for cardiovascular cause, acute myocardial infarction, stent thrombosis, target vessel revascularization and bleeding; the secondary endpoints were death for any reason or cardiovascular cause and stroke. The significance level adopted in the statistical analysis was 5%. Results: Median age was 63 years; 78.5% of the patients were receiving DAPT treatment for acute coronary syndrome. The rates of hospitalization for cardiovascular reasons, acute myocardial infartion, stent thrombosis and target-vessel revascularization were 7.9%, 2.3%, 1.3% and 4.2%, respectively. While the rate of BARC type 1 bleeding was 3.3%, the rate of BARC type 5, 3, or 2 bleeding was 0.6%. The secondary endpoints which were death from any cause, cardiovascular death and stroke were 0.5%, 0.3% and 0.3%, respectively. Conclusion: Our study shows that fixed-dose combination therapy is effective and safe in appropriately selected patients with acute or chronic coronary syndromes.
Anahtar kelimeler
Atıf için künye
Öz, A., Toprak, K., Aydin, E., Saraç, İ., Doğduş, M., Opan, S., Yenerçağ, M., Tascanov, M. B., Kümet, Ö., Karaağaç, M., Özmen, M., Murat, B., Kertmen, Ö., Bekler, Ö., İnci, S., Huyut, M. A., Özderya, A., Er, F., Duran, M., … Zoghi, M. (2024). Fixed-Dose Antiplatelet Dual Combination in Patients with Coronary Artery Disease in Turkish Population: DAPT-TR Terapia Antiplaquetária Dupla Combinada em Pacientes com Doença Arterial Coronariana em uma População na Turquia: DAPT-TR. Arquivos Brasileiros de Cardiologia, 121(11). https://doi.org/10.36660/abc.20240202
BibTeX
@article{oz2024-244810,
author = {Öz, Ahmet and Toprak, Kenan and Aydin, Ertan and Saraç, İbrahim and Doğduş, Mustafa and Opan, Selçuk and Yenerçağ, Mustafa and Tascanov, Mustafa Begenc and Kümet, Ömer and Karaağaç, Miraç and Özmen, Murat and Murat, Bektaş and Kertmen, Ömer and Bekler, Özkan and İnci, Sinan and Huyut, Mustafa Ahmet and Özderya, Ahmet and Er, Fahri and Duran, Mustafa and Ardahanlı, İsa and Baş, Mehmet Memduh and Güzel, Tuncay and Ceyhun, Gökhan and Özdemir, İbrahim Halil and Özen, Mehmet Burak and Gündüz, Ramazan and Erdoğan, Aslan and Çetin, İlyas and Barış, Veysel Özgür and Yayla, Çağrı and Karaduman, Medeni and Aşkın, Lütfü and Bekar, Lütfü and Tanrıverdi, Okan and Özkan, Eyüp and Yeşil, Emrah and Çalışkan, Serhat and Kuzu, Zülfiye and Uğuz, Berat and Böyük, Ferit and Kunak, Ayşegül Ülgen and Murat, Selda and Asil, Serkan and Kayhan, Özkan and Erdoğan, Emrah and Duz, Ramazan and Katkat, Fahrettin and Ekin, Tuba and İbişoğlu, Ersin and Ateş, Bilge Nazar and Ayça, Burak and Ergene, Asım Oktay and Zoghi, Mehdi},
title = {Fixed-Dose Antiplatelet Dual Combination in Patients with Coronary Artery Disease in Turkish Population: DAPT-TR Terapia Antiplaquetária Dupla Combinada em Pacientes com Doença Arterial Coronariana em uma População na Turquia: DAPT-TR},
journal = {Arquivos Brasileiros de Cardiologia},
year = {2024},
volume = {121},
number = {11},
issn = {0066-782X},
doi = {10.36660/abc.20240202},
url = {https://akademik.atauni.edu.tr/yayinlar/244810-fixed-dose-antiplatelet-dual-combination-in-patients-with-coronary-artery}
}