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Makale Tam Makale Uluslararası 2015

Tnf-alpha inhibition by infliximab as a new target for the prevention of glycerol-contrast-induced nephropathy

Murat Saritemur, Harun Un, Elif Çadırcı, Emre Karakus, Erol Akpınar, Zekai Halıcı, Rüstem Anıl Uğan, Adem Karaman, Hasan Tarik Atmaca

ENVIRONMENTAL TOXICOLOGY AND PHARMACOLOGY Cilt 39 · Sayı 2 · ss. 577–588 · 01.03.2015
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Özet

Contrast medium-induced nephropathy (CIN) remains as a problem with high incidence and mortality rates. The aim of this study is to examine the roles of infliximab (INF) in the glycerol (GLY) and CIN model in rats. The rats were separated into five groups (n=8): Healthy, GLY, GLY+CM, GLY+CM+INF 5 mg/kg intraperitoneally (i.p.), and GLY+CM+INF 7 mg/kg (i.p.). Antioxidant levels in the therapy groups were observed to be quite similar to those in the healthy group. In this study, while the kidney TNF-alpha, TGF-1 beta and Caspase 3 gene expressions' levels increased in the nephrotoxic groups, these levels were found to have decreased in the treatment groups. Moreover, histopathologic examination showed that hyaline, haemorrhagic casts and necrosis were increased in nephrotoxicity group, whereas they decreased in the therapy group. Furthermore, TNF-alpha and NF-kappa B expression were decreased with infliximab administrated groups similar to control group. In conclusion, we suggest that infliximab have protective roles on CIN. (C) 2015 Elsevier B.V. All rights reserved.

Anahtar kelimeler

EXPRESSION INFLAMMATION cell death rats MODEL Rat ACUTE-RENAL-FAILURE Contrast media nephrotoxicity MEDIA ACUTE KIDNEY INJURY infliximab CISPLATIN NEPHROTOXICITY PRETREATMENT

Sürdürülebilir Kalkınma Amaçları

  • SKA 3: Sağlıklı Bireyler

Atıf için künye

Saritemur, M., Un, H., Çadırcı, E., Karakus, E., Akpınar, E., Halıcı, Z., Uğan, R. A., Karaman, A., & Atmaca, H. T. (2015). Tnf-alpha inhibition by infliximab as a new target for the prevention of glycerol-contrast-induced nephropathy. ENVIRONMENTAL TOXICOLOGY AND PHARMACOLOGY, 39(2), 577–588. https://doi.org/10.1016/j.etap.2015.01.002

BibTeX 
@article{saritemur2015-24468,
  author = {Saritemur, Murat and Un, Harun and Çadırcı, Elif and Karakus, Emre and Akpınar, Erol and Halıcı, Zekai and Uğan, Rüstem Anıl and Karaman, Adem and Atmaca, Hasan Tarik},
  title = {Tnf-alpha inhibition by infliximab as a new target for the prevention of glycerol-contrast-induced nephropathy},
  journal = {ENVIRONMENTAL TOXICOLOGY AND PHARMACOLOGY},
  year = {2015},
  volume = {39},
  number = {2},
  pages = {577--588},
  issn = {1382-6689},
  doi = {10.1016/j.etap.2015.01.002},
  url = {https://akademik.atauni.edu.tr/yayinlar/24468-tnf-alpha-inhibition-by-infliximab-as-a-new-target-for-the-prevention-of}
}