Role of endothelin receptors and relationship with nitric oxide synthase in impaired erectile response in diabetic rats
Özet
To evaluate the protective role of bosentan (BOS), an endothelin-1 (ET-1) receptor antagonist, and to show the changes in rats with experimentally induced diabetic erectile dysfunction (ED), a total of 24 albino Wistar rats were allocated into four groups. Group 1 was the healthy group and Group 2 had diabetes mellitus (DM) induced by intraperitoneal injection of 60mgkg(-1) streptozotocin (STZ). Following the establishment of DM, Group 3 and Group 4 were treated with oral BOS doses of 50mgkg(-1) and 100mgkg(-1), respectively, for 60days. At the end of the treatment, we evaluated yawning and erection response to apomorphine treatment and then the animals were sacrificed. ET-1, eNOS, iNOS, tumour necrosis factor (TNF)-, ET-RA and ET-RB mRNA expressions were analysed in cavernosal tissue. It was observed that yawning and erection response decreased in the diabetic group; however, both of these improved with BOS treatment. While ET-1, TNF- and iNOS gene expressions increased, eNOS, ET-RA and ET-RB gene expressions decreased in the DM group compared to the healthy group. DM has a negative impact on cavernosal tissue blood flow through activating vasoconstrictor mediators in cavernosal tissue. BOS regulates significantly eNOS, iNOS and TNF- expressions in a dose-dependent manner.
Anahtar kelimeler
Sürdürülebilir Kalkınma Amaçları
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SKA 3: Sağlıklı Bireyler
Atıf için künye
ALKAN, E., Uğan, R. A., BASAR, M. M., Halıcı, Z., KARAKUS, E., BALBAY, M. D., & Un, H. (2017). Role of endothelin receptors and relationship with nitric oxide synthase in impaired erectile response in diabetic rats. ANDROLOGIA, 49(2). https://doi.org/10.1111/and.12607
BibTeX
@article{alkan2017-24465,
author = {ALKAN, Emre and Uğan, Rüstem Anıl and BASAR, M. M. and Halıcı, Zekai and KARAKUS, Emre and BALBAY, M. D. and Un, H.},
title = {Role of endothelin receptors and relationship with nitric oxide synthase in impaired erectile response in diabetic rats},
journal = {ANDROLOGIA},
year = {2017},
volume = {49},
number = {2},
issn = {0303-4569},
doi = {10.1111/and.12607},
url = {https://akademik.atauni.edu.tr/yayinlar/24465-role-of-endothelin-receptors-and-relationship-with-nitric-oxide-synthase-in}
}