Protection against the cisplatin-induced testis injury by administering Ceratonia siliqua L. extract in Sprague dawley rats
Özet
The purpose of this study was to show the
possible ameliorative effect of Ceratonia
siliqua L. (CS) extract on the cisplatin
(CP) induced testis damage in rats. The
physiological saline was applied to the
control group and CS was injected in two
different doses for two groups, that is, the
low-dose CS group and the high dose
group. The CP injection was divided into
three groups (CP group, CP + low dose
CS group, CP + high dose CS group). At
the end of the experiment, the animals
were sacrificed and their testis tissues
were removed for the biochemical and
histopathological investigation. Total
antioxidant status (TAS) and total
oxidant status (TOS) levels were
determined and finally the
histopathological changes int he testis
tissues were examined using
hematoxylin-eosin staining method. It
was found that applying CS extract could
revert the level of fertility hormones and
suppress the histomorphological
alterations and DNA damages. CS
provided the evidence that it might have
a therapeutic role in free radical mediated
diseases
Atıf için künye
Yıldız Deniz, G., Laloğlu, E., Çomaklı, S., Gezer, A., & Yigit, N. (2022). Protection against the cisplatin-induced testis injury by administering Ceratonia siliqua L. extract in Sprague dawley rats. Journal of Basic Health, 1(1), 1–11. https://dergipark.org.tr/en/pub/jobah/issue/72998/1187917
BibTeX
@article{yildizdeniz2022-244535,
author = {Yıldız Deniz, Gülşah and Laloğlu, Esra and Çomaklı, Selim and Gezer, Arzu and Yigit, Nimet},
title = {Protection against the cisplatin-induced testis injury by administering Ceratonia siliqua L. extract in Sprague dawley rats},
journal = {Journal of Basic Health},
year = {2022},
volume = {1},
number = {1},
pages = {1--11},
url = {https://akademik.atauni.edu.tr/yayinlar/244535-protection-against-the-cisplatin-induced-testis-injury-by-administering}
}