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Makale Tam Makale Uluslararası 2020

Do peripheral melatonin agonists improve bone fracture healing? The effects of agomelatine and ramelteon on experimental bone fracture

Duygu Köse, Ahmet Kose, Zekai Halıcı, Muhammet Ali Gürbüz, Ali Aydın, Rüstem Anıl Uğan, Adem Karaman, Erdem Toktay

EUROPEAN JOURNAL OF PHARMACOLOGY Cilt 887 · 01.11.2020
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Özet

Melatonin improves fracture healing, but the long-term use of melatonin seems impracticable in the treatment of fracture due to side effects caused by hormonal stress on chronological rhythm. Ramelteon (RAMEL) and agomelatine (AGO) are non-selective peripheral melatonin receptor (MT) agonists. This study investigated the effects on bone fracture healing of these MT agonists, which do not affect the central nervous system.

Anahtar kelimeler

Agomelatine Melatonine Ramelteon Fracture healing

Sürdürülebilir Kalkınma Amaçları

  • SKA 3: Sağlıklı Bireyler

Atıf için künye

Köse, D., Kose, A., Halıcı, Z., Gürbüz, M. A., Aydın, A., Uğan, R. A., Karaman, A., & Toktay, E. (2020). Do peripheral melatonin agonists improve bone fracture healing? The effects of agomelatine and ramelteon on experimental bone fracture. EUROPEAN JOURNAL OF PHARMACOLOGY, 887. https://doi.org/10.1016/j.ejphar.2020.173577

BibTeX
@article{kose2020-24442,
  author = {Köse, Duygu and Kose, Ahmet and Halıcı, Zekai and Gürbüz, Muhammet Ali and Aydın, Ali and Uğan, Rüstem Anıl and Karaman, Adem and Toktay, Erdem},
  title = {Do peripheral melatonin agonists improve bone fracture healing? The effects of agomelatine and ramelteon on experimental bone fracture},
  journal = {EUROPEAN JOURNAL OF PHARMACOLOGY},
  year = {2020},
  volume = {887},
  issn = {0014-2999},
  doi = {10.1016/j.ejphar.2020.173577},
  url = {https://akademik.atauni.edu.tr/yayinlar/24442-do-peripheral-melatonin-agonists-improve-bone-fracture-healing-the-effects-of}
}