The relationship between glomerular IgG staining and poor prognostic findings in patients with IgA nephropathy: the data from TSN-GOLD working group.
Özet
Background Galactose-deficient IgA1 (Gd-IgA1) has an increased tendency to form immunocomplexes with IgG in the serum, contributing to IgAN pathogenesis by accumulating in the glomerular mesangium. Several studies showed that glomerular IgG deposition in IgAN is an important cause of mesangial proliferation and glomerular damage. This study aims to determine the association of the positivity of IgG and the intensity of IgG staining with a poor renal prognosis. Methods A total of 943 IgAN patients were included in the study. Glomerular IgG staining negative and positive patients were compared using Oxford classification scores, histopathological evaluations, proteinuria, eGFR, albumin, blood pressures. IgG positive patients were classified as (+), (++), (+++) based on their staining intensity, and the association with the prognostic criteria was also evaluated. Results 81% (n = 764) of the patients were detected as IgG negative, while 19% (n = 179) were positive. Age, gender, body mass index, blood pressure, proteinuria, eGFR, uric acid values were similar in IgG positive and negative patients who underwent biopsy (p > 0.05). Intensity of glomerular IgG positivity was not found to be associated with diastolic and systolic blood pressure, urea, uric acid, age, eGFR, albumin, proteinuria (p > 0.05 for all, r = - 0.084, r = - 0.102, r = - 0.006, r = 0.062, r = 0.014, r = - 0.044, r = - 0.061, r = - 0.066, r = 0.150, respectively). There was no difference for histopathological findings between IgG (+), IgG (++), IgG (+++) groups (for all, p > 0.05). Conclusion Glomerular IgG negativity and positivity detected by routine IFM in IgAN patients is not associated with poor renal prognostic risk factors.
Anahtar kelimeler
Atıf için künye
Turgutalp, K., Cebeci, E., Turkmen, A., Derici, U., Seyahi, N., Eren, N., Dede, F., Gullulu, M., Basturk, T., Sahin, G. M., Yilmaz, M., Sipahi, S., Sahin, G., Ulu, S., Tatar, E., Gundogdu, A., Kazancioglu, R. T., Sevinç, C., Gungor, O., … Ozturk, S. (2021). The relationship between glomerular IgG staining and poor prognostic findings in patients with IgA nephropathy: the data from TSN-GOLD working group. BMC NEPHROLOGY, 22(1), 352. https://doi.org/10.1186/s12882-021-02560-2
BibTeX
@article{turgutalp2021-243691,
author = {Turgutalp, Kenan and Cebeci, Egemen and Turkmen, Aydin and Derici, Ulver and Seyahi, Nurhan and Eren, Necmi and Dede, Fatih and Gullulu, Mustafa and Basturk, Taner and Sahin, Gulizar Manga and Yilmaz, Murvet and Sipahi, Savas and Sahin, Garip and Ulu, Sena and Tatar, Erhan and Gundogdu, Ali and Kazancioglu, Rumeyza Turan and Sevinç, Can and Gungor, Ozkan and Sahin, İdris and Kutlay, Sim and Kurultak, Ilhan and Aydin, Zeki and Altun, Bulent and Dursun, Belda and Yilmaz, Zulfikar and Uzun, Ozcan and Suleymanlar, Gultekin and Candan, Ferhan and Sezer, Siren and Tanburoglu, Derya Basak and Bahcebasi, Zerrin Bicik and Taymez, Dilek and Akcali, Esra and Oygar, Deren and Istemihan, Zulal and Bardak, Simge and Akcay, Omer Faruk and Dincer, Mevlut Tamer and Dervisoglu, Erkan and Yenigun, Ezgi and Turkmen, Kultigin and Ozturk, Savas},
title = {The relationship between glomerular IgG staining and poor prognostic findings in patients with IgA nephropathy: the data from TSN-GOLD working group.},
journal = {BMC NEPHROLOGY},
year = {2021},
volume = {22},
number = {1},
pages = {352},
issn = {1471-2369},
doi = {10.1186/s12882-021-02560-2},
url = {https://akademik.atauni.edu.tr/yayinlar/243691-the-relationship-between-glomerular-igg-staining-and-poor-prognostic-findings-in}
}