Biopsy-proven BK virus nephropathy in renal transplant recipients: A multi-central study from Turkey (BK-TURK STUDY)
Özet
Aim: BK polyomavirus infection is a challenging complication of renal transplantation. The management is not standardized and is based on reports from transplantation centers' experiences, usually with small sample sizes. Therefore, we aimed to present our countrywide experience with BK virus nephropathy (BKVN) in renal transplant recipients. Materials and methods: Our study was carried out with the participation of 30 transplantation centers from all regions of Turkey. Only cases with allograft biopsy-proven BKVN were included in the study. Results: 13,857 patients from 30 transplantation centers were screened, and 207 BK nephropathy cases were included. The mean age was 46.4 +/- 13.1 years, and 146 (70.5%) patients were male. The mean time to diagnosis of BK nephropathy was 15.8 +/- 22.2 months after transplantation. At diagnosis, the mean creatinine level was 1.8 +/- 0.7 mg/dL, and the mean estimated glomerular filtration rate was 45.8 +/- 19.6 mL/min/1.73m2. 2 . In addition to dose reduction or discontinuation of immunosuppressive drugs, 18 patients were treated with cidofovir, 11 patients with leflunomide, 17 patients with quinolones, 15 patients with intravenous immunoglobulin (IVIG), 5 patients with cidofovir plus IVIG, and 12 patients with leflunomide plus IVIG. None of the patients receiving leflunomide or leflunomide plus IVIG had allograft loss. During follow-up, allograft loss occurred in 32 (15%) out of 207 patients with BK nephropathy. Conclusion: BKVN is still a frequent cause of allograft loss in kidney transplantation and is not fully elucidated. The results of our study suggest that leflunomide treatment is associated with more favorable allograft outcomes.
Atıf için künye
Gungor, O., DHEİR, H., Islam, M., TÖZ, H., YILDIZ, A., Sinangil, A., Tatar, E., AŞCI, G., ULUTAŞ, Ö., Altun, E., ALTUNÖREN, O., Apaydin, S., ERSOY, A., KORUCU, B., Safak, S., DERİCİ, Ü., YILDIRIM, S., SEYAHİ, N., Ozcan, S. G., … Turkmen, A. (2024). Biopsy-proven BK virus nephropathy in renal transplant recipients: A multi-central study from Turkey (BK-TURK STUDY). CLINICAL NEPHROLOGY. https://doi.org/10.5414/cn111300
BibTeX
@article{gungor2024-243670,
author = {Gungor, Ozkan and DHEİR, HAMAD and Islam, Mahmud and TÖZ, HÜSEYİN and YILDIZ, ABDULMECİT and Sinangil, Ayse and Tatar, Erhan and AŞCI, GÜLAY and ULUTAŞ, ÖZKAN and Altun, Eda and ALTUNÖREN, ORÇUN and Apaydin, Suheyla and ERSOY, ALPARSLAN and KORUCU, BERFU and Safak, Seda and DERİCİ, ÜLVER and YILDIRIM, SALİHA and SEYAHİ, NURHAN and Ozcan, Seyda Gul and Atilgan, Kadir Gokhan and Ayli, Mehmet Deniz and ÇAVDAR, CANER and UZUN, ÖZCAN and Yilmaz, Rahmi and ERDUT, ARDA and Sevinc, Mustafa and Kasapoglu, Umut and KOÇYİĞİT, İSMAİL and UYSAL, CİHAN and Turkmen, Kultigin and Ozer, Hakan and VELİOĞLU, ARZU and Ok, Ebru and KAYA, BÜLENT and Yilmaz, Zulfikar and Ozkan, Oktay and Cebeci, Egemen and TURGUTALP, KENAN and GÜRSU, Meltem and Yuksel, Enver and EREN, NECMİ and DERVİŞOĞLU, ERKAN and Guzel, Fatma Betul and Yildiz, Gursel and BAKIRDÖĞEN, SERKAN and Inci, Ayca and Sevinç, Can and Turkmen, Aydin},
title = {Biopsy-proven BK virus nephropathy in renal transplant recipients: A multi-central study from Turkey (BK-TURK STUDY)},
journal = {CLINICAL NEPHROLOGY},
year = {2024},
issn = {0301-0430},
doi = {10.5414/cn111300},
url = {https://akademik.atauni.edu.tr/yayinlar/243670-biopsy-proven-bk-virus-nephropathy-in-renal-transplant-recipients-a-multi}
}