Candidemia in Turkey demonstrates nationwide predominance of non-albicans Candida and Candida auris detection
Özet
In recent years, evolving patterns in candidemia epidemiology, including increasing proportions of non-albicans Candida (NAC) species and the emergence of Candida auris,
have been reported. We aimed to characterize contemporary candidemia
epidemiology in Turkey and to assess the association between guideline
adherence and 30-day mortality. In this nationwide retrospective
multicenter cohort study, adult patients with blood culture–confirmed
candidemia diagnosed between January 2022 and December 2023 in 20
hospitals were included. Species identification was standardized and
confirmed using MALDI-TOF MS. A total of 398 candidemia episodes were
analyzed. Although Candida albicans remained the single most common species (34.7%), NAC species predominated overall (65.3%), mainly driven by Candida parapsilosis (26.6%), while C. auris
accounted for 6.5% of cases and was detected across multiple centers.
Crude mortality was 68.3% and 30-day mortality was 56.3%. Failure to
remove central venous catheters (CVC) was independently associated with
higher 30-day mortality. Kaplan–Meier analysis demonstrated significant
differences in 30-day survival across EQUAL Candida score
categories in the overall candidemia cohort (log-rank p = 0.02) and
among patients with CVC-related candidemia cohort (log-rank p = 0.008).
Collectively, our findings provide a contemporary nationwide overview of
candidemia in Turkey, highlighting the predominance of NAC species, the
multicenter detection of C. auris, and the clinical importance of early source control.
Atıf için künye
Karakoç, Z. Ç., Gülcan, A., Ener, B., Ertürk Şengel, B., Mıstanoğlu Özatağ, D., Tanrıverdi, E. S., Kazak, E., Memişoğlu, F., Alay, H., Saltoğlu, N., & Gündoğdu Aksoy, F. (2026). Candidemia in Turkey demonstrates nationwide predominance of non-albicans Candida and Candida auris detection. SCIENTIFIC REPORTS, 16(1), 1–28. https://doi.org/10.1038/s41598-026-53506-3
BibTeX
@article{karakoc2026-242732,
author = {Karakoç, Zehra Çağla and Gülcan, Aynur and Ener, Beyza and Ertürk Şengel, Buket and Mıstanoğlu Özatağ, Duru and Tanrıverdi, Elif Seren and Kazak, Esra and Memişoğlu, Funda and Alay, Handan and Saltoğlu, Neşe and Gündoğdu Aksoy, Feyzanur},
title = {Candidemia in Turkey demonstrates nationwide predominance of non-albicans Candida and Candida auris detection},
journal = {SCIENTIFIC REPORTS},
year = {2026},
volume = {16},
number = {1},
pages = {1--28},
issn = {2045-2322},
doi = {10.1038/s41598-026-53506-3},
url = {https://akademik.atauni.edu.tr/yayinlar/242732-candidemia-in-turkey-demonstrates-nationwide-predominance-of-non-albicans}
}