Profiles of primary brain abscesses and their impact on survival: An international ID-IRI study
Özet
Objectives: This study of 331 primary brain abscess (PBA) patients aimed to understand infecting agents, predisposing factors, and outcomes, with a focus on factors affecting mortality. Methods: Data were collected from 39 centers across 16 countries between January 2010 and December 2022, and clinical, radiological, and microbiological findings, along with their impact on mortality, were analyzed. Results: The patients had a mean ± SD age of 46.8 ± 16.3 years, with a male predominance of 71.6%. Common symptoms included headache (77.9%), fever (54.4%), and focal neurological deficits (53.5%). Gram-positive cocci were the predominant pathogens, with Viridans group streptococci identified as the most frequently isolated organisms. All patients received antimicrobial therapy and 71.6% underwent interventional therapies. The 42-day and 180-day survival rates were 91.9% and 86.1%, respectively. Significant predictors of 42-day mortality included intravenous drug addiction (HR: 6.02, 95% CI: 1.38-26.26), malignancy (HR: 3.61, 95% CI: 1.23-10.58), confusion (HR: 2.65, 95% CI: 1.19-5.88), and unidentified bacteria (HR: 4.68, 95% CI: 1.76-12.43). Significant predictors of 180-day mortality included malignancy (HR: 2.70, 95% CI: 1.07-6.81), confusion (HR: 2.14, 95% CI: 1.11-4.15), temporal lobe involvement (HR: 2.10, 95% CI: 1.08-4.08), and unidentified bacteria (HR: 3.02, 95% CI: 1.49-6.15). Conclusion: The risk of death in PBA extends beyond the infection phase, with different factors influencing the 42-day and 180-day mortality rates. Intravenous drug addiction was associated with early mortality, while temporal lobe involvement was associated with late mortality.
Anahtar kelimeler
Atıf için künye
ŞAHİN, M., MERT, A., Emecen, A. N., Strunjas, N. P., Fasanekova, L., Batirel, A., Darazam, I. A., Ansari, S., Firouzjaei, G. G., Stebel, R., Tigen, E. T., Sengel, B. E., Dzupova, O., Belitova, M., Abid, M., Demirbaş, N. D., Erol, S., Kul, H., Pekok, A. U., … Erdem, H. (2024). Profiles of primary brain abscesses and their impact on survival: An international ID-IRI study. INTERNATIONAL JOURNAL OF INFECTIOUS DISEASES, 147. https://doi.org/10.1016/j.ijid.2024.107228
BibTeX
@article{sahin2024-242726,
author = {ŞAHİN, Meyha and MERT, Ali and Emecen, Ahmet Naci and Strunjas, Natalija Planinc and Fasanekova, Lenka and Batirel, Ayse and Darazam, Ilad Alavi and Ansari, Shabboo and Firouzjaei, Ghazaleh Golchoub and Stebel, Roman and Tigen, Elif Tukenmez and Sengel, Buket Erturk and Dzupova, Olga and Belitova, Maya and Abid, Maha and Demirbaş, Nazife Duygu and Erol, Serpil and Kul, Halil and Pekok, Abdullah Umut and Ulusoy, Tülay Ünver and Alay, Handan and Amiri, Zahra Mohtasham and Cascio, Antonio and Karadağ, Mehmet Kürşat and Kolovani, Entela and Mladenov, Nikolay and Ramosaco, Ergys and Sipahi, Oğuz Reşat and Şanlıdağ, Gamze and El-Kholy, Amani and Okay, Gulay and Pshenichnaya, Natalia and Şahinoğlu, Mustafa Serhat and Alkan, Sevil and Özdemir, Mehmet and Rahimi, Bilal Ahmad and Karlidag, Gulden Eser and Balin, Şafak Özer and Liskova, Anna and Jouhar, Anas and Almajid, Fahad and Artur, Xhumari and Çelik, Mehmet and Khan, Asfandiyar and Lanzafame, Massimiliano and Marıno, Andrea and Şenol, Arzu and Oncu, Serkan and Uğuz, Mustafa and Zajkowska, Joanna and Erdem, Hakan},
title = {Profiles of primary brain abscesses and their impact on survival: An international ID-IRI study},
journal = {INTERNATIONAL JOURNAL OF INFECTIOUS DISEASES},
year = {2024},
volume = {147},
issn = {1201-9712},
doi = {10.1016/j.ijid.2024.107228},
url = {https://akademik.atauni.edu.tr/yayinlar/242726-profiles-of-primary-brain-abscesses-and-their-impact-on-survival-an}
}