Comparison of Del Nido (a different application) and crystalloid blood cardioplegia on arrhythmia and early results

Abstract

Background The results of the use of del-Nido(DN) solution using a different method or crystalloid blood

cardioplegia in coronary bypass patients were compared. We aimed to investigate the effects on intraoperative and

postoperative arrhythmias, arrhythmia durations and early results.

Methods The study included 175 patients using crystalloid blood cardioplegia (Group 1) and 150 patients using DN

solution(Group 2). In the DN group, 75% of the calculated plegia dose was given first. the remaining part was applied

by giving from grafts. Intraoperative/postoperative data were compared.

Results There was no significant difference between the groups in terms of demographic characteristics. Preop

troponin level was similar.(p=0.190) However, there was a statistical difference between the postoperative 6th hour.

(p=0.001) There was no difference in troponin values at the postoperative 24th hour. (p=0.631) Spontaneous rhythm

occurred at the cardiopulmonary by pass (CPB) weaning stage in most of the patients in Group 2 (95.3%). Although

the need for temporary pacing was less in Group 2, it was not significant.(p=0.282) No patient required permanent

pacing. CPB duration, cross clamp times and intraoperative glucose levels, intensive care follow-up times and

hospitalization times were found to be shorter in Group 2. Although the postoperative atrial fibrillation frequency was

similar (p=0.261), the time to return to sinus was lower in Group 2.(p=0.001).

Conclusion The use of DN cardioplegia solution provides significant positive contributions to avoid arrhythmias

compared to crystalloid blood cardioplegia. DN solution applied with this method may contribute to reducing the

anxieties associated with its use in isolated coronary artery bypass surgery.

Keywords Del nido cardioplegia, Arrhythmia, Coronary artery bypass surgery