Clinicopathologic Features and Prognostic Significance of Immunohistochemistry and In Situ Hybridization Based Molecular Classification in Gastric Carcinoma

Issin, Gizem; SAYAR, İLYAS; DEMİR, FATİH; Bakkaloglu, Irem Guvendir; Gamsizkan, Mehmet; Yildiz, Zeliha; Yilmaz, Ismail; Özmen, Sevilay; ÇAĞATAY, DİREN VUSLAT; Zemheri, Itir Ebru; Demiriz, Murat; Gunal, Armagan

doi:10.1615/jenvironpatholtoxicoloncol.2023047662

Makale Tam Makale Uluslararası 2023 Açık erişimli

Clinicopathologic Features and Prognostic Significance of Immunohistochemistry and In Situ Hybridization Based Molecular Classification in Gastric Carcinoma

Gizem Issin, İLYAS SAYAR, FATİH DEMİR, Irem Guvendir Bakkaloglu, Mehmet Gamsizkan, Zeliha Yildiz, Ismail Yilmaz, Sevilay Özmen, DİREN VUSLAT ÇAĞATAY, Itir Ebru Zemheri, Murat Demiriz, Armagan Gunal

JOURNAL OF ENVIRONMENTAL PATHOLOGY TOXICOLOGY AND ONCOLOGY Cilt 42 · Sayı 4 · ss. 1–14 · 01.01.2023

DOI ile aç

Özet

Background/Aim: Gastric carcinoma (GC) is a highly heterogeneous disease with many subtypes that have different morphologic and molecular characteristics. In the current study, we analyzed immunohistochemical (IHC) and in situ hybridization (ISH) features of GCs and evaluated their association with prognosis and clinicopathological features. Materials and Methods: Three hundred cases analyzed by IHC and ISH for microsatellite stability, p53, e-cadherin, HER2, PD-L1 expression, and Epstein-Barr virus (EBV) status. Cases were classified into five subgroups based on expression profile. The relationships between subgroups, clinicopathological features, and survival were determined. Results: Ten ( 3.3%) cases were classified as EBV-associated, 45 (15%) as microsatellite instable (MSI), 73 (24.3%) as EBV-/ microsatellite-stable (MSS)/epithelial-mesenchymal-transformation (EMT)-like, 75 (25%) as EBV-/MSS/ non-EMT-like/p53+, and 97 (32.3%) as EBV-/MSS/non-EMT-like/ p53-. The MSI subtype had the best overall survival (OS). In contrast, the EBV-/MSS/EMT-like subtype had the poorest OS. The MSI subtype was also related with old age of the patient and antrum-corpus localized tumors, whereas the EBV-/MSS/EMT-like was associated with young age, larger tumor size, and advanced stage presentation. PD-L1 positivity is highly correlated with MSI and EBV-associated subtypes. Conclusion: Our data demonstrated a link between IHC/ISH characteristics of GC and clinical outcomes. IHC/ISH based molecular classification may be helpful in predicting the survival.

Sürdürülebilir Kalkınma Amaçları

SKA 3: Sağlıklı Bireyler

Atıf için künye

Issin, G., SAYAR, İ., DEMİR, F., Bakkaloglu, I. G., Gamsizkan, M., Yildiz, Z., Yilmaz, I., Özmen, S., ÇAĞATAY, D. V., Zemheri, I. E., Demiriz, M., & Gunal, A. (2023). Clinicopathologic Features and Prognostic Significance of Immunohistochemistry and In Situ Hybridization Based Molecular Classification in Gastric Carcinoma. JOURNAL OF ENVIRONMENTAL PATHOLOGY TOXICOLOGY AND ONCOLOGY, 42(4), 1–14. https://doi.org/10.1615/jenvironpatholtoxicoloncol.2023047662

BibTeX

@article{issin2023-239977,
  author = {Issin, Gizem and SAYAR, İLYAS and DEMİR, FATİH and Bakkaloglu, Irem Guvendir and Gamsizkan, Mehmet and Yildiz, Zeliha and Yilmaz, Ismail and Özmen, Sevilay and ÇAĞATAY, DİREN VUSLAT and Zemheri, Itir Ebru and Demiriz, Murat and Gunal, Armagan},
  title = {Clinicopathologic Features and Prognostic Significance of Immunohistochemistry and In Situ Hybridization Based Molecular Classification in Gastric Carcinoma},
  journal = {JOURNAL OF ENVIRONMENTAL PATHOLOGY TOXICOLOGY AND ONCOLOGY},
  year = {2023},
  volume = {42},
  number = {4},
  pages = {1--14},
  issn = {0731-8898},
  doi = {10.1615/jenvironpatholtoxicoloncol.2023047662},
  url = {https://akademik.atauni.edu.tr/yayinlar/239977-clinicopathologic-features-and-prognostic-significance-of-immunohistochemistry}
}