Low serum A-SYNUCLEIN and oligomer A-SYNUCLEIN levels in multiple sclerosis patients
Özet
Introduction: Multiple sclerosis (MS) is an autoimmune, inflammatory, demyelinating neurodegenerative disease progressing with attacks. Alpha-synuclein (alpha-Syn), a neuronal protein, has been previously associated with the inflammation and development of neurodegenerative diseases. Although the cause of neurodegeneration in multiple sclerosis is mainly associated with inflammation, alpha-Syn may play a role in the pathogenesis of MS, as in other classical neurodegenerative diseases such as synucleinopathies. In multiple sclerosis, alpha-Syn has been directly studied in central nervous system lesions and cerebrospinal fluid (CSF). However, there are few studies approaching variations in peripheral alpha-Syn in MS. The aim of our study was to investigate the correlation between disease progression and other clinical parameters by measuring serum alpha-Syn and oligomer alpha-Syn levels in MS patients.
Atıf için künye
Bilge, N., Şimşek, F., Yevgi, R., Ceylan, M., & Aşkın, S. (2021). Low serum A-SYNUCLEIN and oligomer A-SYNUCLEIN levels in multiple sclerosis patients. JOURNAL OF NEUROIMMUNOLOGY, 350. https://doi.org/10.1016/j.jneuroim.2020.577432
BibTeX
@article{bilge2021-237847,
author = {Bilge, Nuray and Şimşek, Fatma and Yevgi, Recep and Ceylan, Mustafa and Aşkın, Seda},
title = {Low serum A-SYNUCLEIN and oligomer A-SYNUCLEIN levels in multiple sclerosis patients},
journal = {JOURNAL OF NEUROIMMUNOLOGY},
year = {2021},
volume = {350},
issn = {0165-5728},
doi = {10.1016/j.jneuroim.2020.577432},
url = {https://akademik.atauni.edu.tr/yayinlar/237847-low-serum-a-synuclein-and-oligomer-a-synuclein-levels-in-multiple-sclerosis}
}