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Low serum osteopontin levels in individuals with choroid plexus calcification

Recep Yevgi, Nuray Bilge, Fatma Şimşek, Mustafa Ceylan, Dilcan Kotan Dündar, Nazım Kızıldağ

NEUROLOGY ASIA Cilt 27 · Sayı 4 · ss. 1025–1030 · 01.12.2022
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Özet

Background & Objective: The choroid plexus (CP) is a tissue plexus located in the ventricles that

produces hormones and nutrients, primarily cerebrospinal fluid (CSF). CP is also an important

component of the blood CSF barrier. Osteopontin (OPN) is an extracellular matrix protein that plays

a role in various physiological and pathological conditions such as bone reshaping, wound healing,

vascular disorders, and inflammatory diseases. It is considered that OPN physiologically regulate biomineralization in bone tissue and reduce the growth and accumulation of calcium crystals in epithelial

tissues. In our study, the role of OPN in CP calcification was studied. Methods: A total of 90 people,

without any disease but with CP calcification (45 people) and age and gender matched control without

CP calcification (45 people) were studied. Calcified and normal CP tissue was identified in brain

computed tomography (CT) images. Serum OPN levels were measured in individuals with and without

CP calcification using a human OPN enzyme-linked immunosorbent test kit (ELISA) from morning

fasting venous blood samples. Results: Serum OPN level was found to be statistically significantly

lower in patients with CP calcification than those without CP calcification (p=0.007).

Conclusions: Our results show that OPN may have a significant role in the calcification process of CP.

Sürdürülebilir Kalkınma Amaçları

  • SKA 1: Yoksulluğa Son
  • SKA 4: Nitelikli Eğitim
  • SKA 5: Cinsiyet Eşitliği

Atıf için künye

Yevgi, R., Bilge, N., Şimşek, F., Ceylan, M., Dündar, D. K., & Kızıldağ, N. (2022). Low serum osteopontin levels in individuals with choroid plexus calcification. NEUROLOGY ASIA, 27(4), 1025–1030. https://doi.org/10.54029/2022cjh

BibTeX 
@article{yevgi2022-237819,
  author = {Yevgi, Recep and Bilge, Nuray and Şimşek, Fatma and Ceylan, Mustafa and Dündar, Dilcan Kotan and Kızıldağ, Nazım},
  title = {Low serum osteopontin levels in individuals with choroid plexus calcification},
  journal = {NEUROLOGY ASIA},
  year = {2022},
  volume = {27},
  number = {4},
  pages = {1025--1030},
  issn = {1823-6138},
  doi = {10.54029/2022cjh},
  url = {https://akademik.atauni.edu.tr/yayinlar/237819-low-serum-osteopontin-levels-in-individuals-with-choroid-plexus-calcification}
}