Blocking of urotensin receptors as new target for treatment of carrageenan induced inflammation in rats

Çadırcı, Elif; Halıcı, Zekai; Yayla, Muhammed; Toktay, Erdem; Bayır, Yasin; Karakus, Emre; TOPÇU, ATİLLA; Buyuk, Basak; Albayrak, Abdulmecit

doi:10.1016/j.peptides.2016.05.006

Makale Tam Makale Uluslararası 2016

Blocking of urotensin receptors as new target for treatment of carrageenan induced inflammation in rats

Elif Çadırcı, Zekai Halıcı, Muhammed Yayla, Erdem Toktay, Yasin Bayır, Emre Karakus, ATİLLA TOPÇU, Basak Buyuk, Abdulmecit Albayrak

PEPTIDES Cilt 82 · ss. 35–43 · 01.08.2016

DOI ile aç

Özet

This study investigated possible role of U-II and its receptor expression in inflammation by using UTR agonist and antagonist in carrageenan induced acute inflammation. Rats were divided into 5 groups as (1) Healthy control, (2) Carrageenan control, (3) Carrageenan +Indomethacin 20 mg/kg, orally, (4) Carrageenan +AC7954 (U-II receptor agonist, intraperitoneally) 30 mg/kg and (5) Carrageenan +SB657510 (UTR antagonist, intraperitoneally) 30 mg/kg. 1 h after drug administration, carrageenan was injected. At the 3rd hour after carrageenan injection, agonist produced no effect while antagonist 63% anti-inflammatory effect respectively. UTR and UT-II expression increased in carrageenan induced paw tissue. Antagonist administration prevented the decrease in an antioxidant system and also capable to decrease TNF-alpha and IL-6 mRNA expressions. This study showed the role of urotensin II receptors in the physiopathogenesis of acute inflammatory response that underlying many diseases accompanied by inflammation. (C) 2016 Elsevier Inc. All rights reserved.

Anahtar kelimeler

TISSUE EXPRESSION IDENTIFICATION INFLAMMATION rats TNF-ALPHA ANTAGONIST PAW INVOLVEMENT Urotensin II SB657510 II-RELATED PEPTIDE ENDOGENOUS LIGAND HEPATIC-FAILURE ORPHAN RECEPTOR

Atıf için künye

Çadırcı, E., Halıcı, Z., Yayla, M., Toktay, E., Bayır, Y., Karakus, E., TOPÇU, A., Buyuk, B., & Albayrak, A. (2016). Blocking of urotensin receptors as new target for treatment of carrageenan induced inflammation in rats. PEPTIDES, 82, 35–43. https://doi.org/10.1016/j.peptides.2016.05.006

BibTeX

@article{cadirci2016-23679,
  author = {Çadırcı, Elif and Halıcı, Zekai and Yayla, Muhammed and Toktay, Erdem and Bayır, Yasin and Karakus, Emre and TOPÇU, ATİLLA and Buyuk, Basak and Albayrak, Abdulmecit},
  title = {Blocking of urotensin receptors as new target for treatment of carrageenan induced inflammation in rats},
  journal = {PEPTIDES},
  year = {2016},
  volume = {82},
  pages = {35--43},
  issn = {0196-9781},
  doi = {10.1016/j.peptides.2016.05.006},
  url = {https://akademik.atauni.edu.tr/yayinlar/23679-blocking-of-urotensin-receptors-as-new-target-for-treatment-of-carrageenan}
}